Peran EMT pada resistensi obat kanker (kemoresistensi) diamati menggunakan model tikus kanker paru dan kanker pankreas. Eksperimen knockdown faktor transkripsi Snail atau Twist menunjukkan peran EMT kurang terlihat pada metastasis kedua model tersebut, tapi lebih kentara dalam menginduksi kemoresistensi.<ref>{{ cite journal|vauthors= KrebsFischer AMKR, MitschkeDurrans A, Lee S, Sheng J, LasierraLi LosadaF, MWong ST dkk | title=Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance | journal = Nature| volume= 527| issue=7579 | pages= 472-6| year= 2015| doi= 10.1038/nature15748}}</ref><ref>{{ cite journal|vauthors= Zheng X, SchmalhoferCarstens OJL, BoerriesKim J, Scheible M, BuschKaye J, Sugimoto H, dkk | title=The EMTEpithelial-activatorto-mesenchymal Zeb1transition is a key factordispensable for cellmetastasis plasticitybut andinduces promotes metastasischemoresistance in pancreatic cancer | journal = NatNature| Cellvolume= Biol527| issue=7579 | pages= 525-30| year= 2015| doi= 10.1038/nature16064}}</ref> Pendorong EMT, Snail, juga telah ditunjukkan mendorong kekambuhan kanker payudara in vivo.<ref>{{ cite journal|vauthors= Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero CP, Sterner CJ, dkk | title=The transcriptional repressor Snail promotes mammary tumor recurrence | journal = Cancer Cell.| volume= 198| issue=53 | pages= 518197-529209| year= 20172005| doi= 10.10381016/ncb3513j.ccr.2005.07.009}}</ref>
