Deferoksamin: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
baru |
Tidak ada ringkasan suntingan |
||
Baris 1:
{{inuseuntil|30
{{Infobox drug
| drug_name =
| INN =
| type =<!-- empty -->
| IUPAC_name = ''N'''-{5-[Acetyl(hydroxy)amino]pentyl}-''N''-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-''N''-hydroxysuccinamide
| image = Deferoxamine-2D-skeletal.png
| width =
| alt =
| image2 = Deferoxamine-3D-vdW.png
| width2 =
| alt2 =
| imageL =
| widthL =
| altL =
| imageR =
| widthR =
| altR =
| caption = Rumus kerangka dan model ruang isi deferoksamin
<!-- Clinical data -->
| pronounce =
| tradename = Desferal
| Drugs.com = {{drugs.com|monograph|deferoxamine-mesylate}}
| MedlinePlus =
| licence_EU = <!-- EMA requires brand name -->
| licence_US = <!-- FDA may use generic name -->
| DailyMedID = <!-- preference to licence_US -->
| pregnancy_AU = <!-- A/B1/B2/B3/C/D/X -->
| pregnancy_AU_comment =
| pregnancy_US = C
| pregnancy_US_comment =
| pregnancy_category=
| dependency_liability =
| addiction_liability =
| routes_of_administration = {{unbulleted list|intramuskular|intravena|subkutan}}
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_AU_comment =
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment =
| legal_DE = <!-- Anlage I, II, III or Unscheduled-->
| legal_DE_comment =
| legal_NZ = <!-- Class A, B, C -->
| legal_NZ_comment =
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->
| legal_UK_comment =
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_US_comment =
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV-->
| legal_UN_comment =
| legal_status = <!--For countries not listed above-->
<!-- Pharmacokinetic data -->
| bioavailability =
| protein_bound =
| metabolism =
| metabolites =
| onset =
| elimination_half-life = 6 jam
| duration_of_action =
| excretion =
<!-- Identifiers -->
| CAS_number = 70-51-9
| CAS_supplemental = {{cascite|correct|CAS}}
| ATCvet =
| ATC_prefix = V03
| ATC_suffix = AC01
| ATC_supplemental =
| PubChem = 2973
| PubChemSubstance =
| IUPHAR_ligand =
| DrugBank = DB00746
| ChemSpiderID = 2867
| UNII = J06Y7MXW4D
| KEGG = D03670
| ChEBI = 4356
| ChEMBL = 556
| NIAID_ChemDB =
| synonyms = desferrioxamine B, desferoxamine B, DFO-B, DFB ,N'-[5-(Acetyl-hydroxy-amino)pentyl]-N-[5-[3-(5-aminopentyl-hydroxy-carbamoyl) propanoylamino]pentyl]-N-hydroxy-butane diamide
<!-- Chemical data -->
| chemical_formula =
| C=25 | H=48 | Ag= | Al= | As= | Au= | B= | Bi= | Br= | Ca= | Cl= | Co= | F= | Fe= | Gd= | I=
| K= | Li= | Mg= | Mn= | N=6 | Na= | O=8 | P= | Pt= | S= | Sb= | Se= | Sr= | Tc= | Zn= | charge=
| molecular_weight =
| SMILES = CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
| Jmol =
| StdInChI = 1S/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34)
| StdInChI_comment = {{stdinchicite|correct|chemspider}}
| StdInChIKey = UBQYURCVBFRUQT-UHFFFAOYSA-N
| density =
| density_notes =
| melting_point =
| melting_high =
| melting_notes =
| boiling_point =
| boiling_notes =
| solubility =
| specific_rotation =
}}
Deferoxamine, dijual dengan nama merek Desferal, adalah obat yang mengikat besi dan aluminium. Ini secara khusus digunakan dalam overdosis besi, hemochromatosis baik karena transfusi darah multipel atau kondisi genetik yang mendasarinya, dan toksisitas aluminium pada orang yang menggunakan dialisis.
| |||