Varian SARS-CoV-2: Perbedaan antara revisi

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{{COVID-19 pandemic sidebar|expanded=medis}}
[[Koronavirus sindrom pernapasan akut berat 2]] (SARS-CoV-2), virus penyebab [https://jnss.eu.org/varian-delta-melonjak-kasus-terbanyak-dki-jakarta/ [penyakit koronavirus 2019]] (COVID-19), memiliki banyak [[Varian (biologi)|varian]]; beberapa di antaranya dipercaya cukup penting. Artikel ini membahas '''varian-varian penting dari SARS-CoV-2''' dan beberapa mutasi penting yang ditemukan di sebagian atau seluruh varian-varian ini.
 
Deret urutan ''WIV04/2019'' yang termasuk klad S [[GISAID]], garis keturunan A [[Pangolin (alat)|Pangolin]], dan klad 19B [[Nextstrain]] kemungkinan menggambarkan pengurutanan genom virus asli yang menginfeksi manusia dan dikenal sebagai "urutan nol". Urutan ini dipakai secara luas dan menjadi urutan rujukan.<ref>{{cite journal |last1=Zhukova |first1=Anna |last2=Blassel |first2=Luc |last3=Lemoine |first3=Frédéric |last4=Morel |first4=Marie |last5=Voznica |first5=Jakub |last6=Gascuel |first6=Olivier |date=24 November 2020 |title=Origin, evolution and global spread of SARS-CoV-2 |journal=Comptes Rendus Biologies |pp=1–20 |url=https://comptes-rendus.academie-sciences.fr/biologies/item/CRBIOL_0__0_0_A1_0/ |doi=10.5802/crbiol.29 |doi-access=free}}</ref>
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=== Garis keturunan B.1.1.7 (Alpha) ===
{{utama|Garis keturunan B.1.1.7}}
[[Garis keturunan B.1.1.7]]<ref>{{cite report |author1=Rambaut, Andrew |author2=Loman, Nick |author3=Pybus, Oliver |author4=Barclay, Wendy |author5=Barrett, Jeff |author6=Carabelli, Alesandro |author7=Connor, Tom |author8=Peacock, Tom |author9=L. Robertson, David |author10=Vol, Erik |year=2020 |title=Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations |publisher=Written on behalf of COVID-19 Genomics Consortium UK |url=https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563 |access-date=20 Desember 2020}}</ref>, disebut juga 20I/501Y.V1 atau Variant of Concern 202012/01 (VOC-202012/01),<ref name="Chand2020">{{cite report |last1=Chand |first1=Meera |last2=Hopkins |first2=Susan |last3=Dabrera |first3=Gavin |last4=Achison |first4=Christina |last5=Barclay |first5=Wendy |last6=Ferguson |first6=Neil |last7=Volz |first7=Erik |last8=Loman |first8=Nick |last9=Rambaut |first9=Andrew |last10=Barrett |first10=Jeff |date=21 Desember 2020 |title=Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01 |publisher=[[Public Health England]] |url=https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/947048/Technical_Briefing_VOC_SH_NJL2_SH2.pdf |access-date=23 Desember 2020}}</ref> sebelumnya dikenal sebagai Variant Under Investigation pertama pada Desember 2020 (VUI-202012/01), pertama kali terdeteksi pada Oktober 2020 selama [[pandemi COVID-19 di Britania Raya]] dari sampel yang diambil bulan sebelumnya.<ref name="CDC">{{cite web |url=https://www.cdc.gov/coronavirus/2019-ncov/more/science-and-research/scientific-brief-emerging-variants.html |author=CDC |title=Emerging SARS-CoV-2 Variants |publisher=Centers for Disease Control and Prevention |language=en-us |access-date=4 Januari 2021}} {{PD-notice}}</ref> Sejak itu, prevalensinya menjadi dua kali lipat setiap 6,5 hari, perkiraan interval generasinya.<ref>{{cite web |url=https://khub.net/documents/135939561/338928724/New+SARS-COV-2+variant+-+information+and+risk+assessment.pdf/b56d4591-0466-1a18-28dc-010e0fdeef53?t=1608569319930 |title=New evidence on VUI-202012/01 and review of the public health risk assessment |date=15 Desember 2020 |website=khub.net}}</ref><ref>{{cite web |url=https://www.youtube.com/watch?v=G3CT9N89L-c&t=9399 |title=COG-UK Showcase Event - YouTube |publisher=YouTube |access-date=25 Desember 2020}}</ref> Varian ini berkorelasi dengan peningkatan yang signifikan pada tingkat infeksi COVID-19 di Britania Raya. Peningkatan ini diperkirakan setidaknya sebagian karena mutasi [[#N501Y|N501Y]]. Pada tanggal 2 Maret 2021, [https://jnss.eu.org/varian[Pandemi COVID-delta-melonjak-kasus-terbanyak-dki-jakarta/19 di Indonesia|Indonesia]] melaporkan kasus pertamanya untuk varian ini.<ref>{{cite news |title=Dua Kasus Mutasi Corona Asal Inggris Ditemukan di Indonesia |date=2 Maret 2021 |work=CNN Indonesia |url=https://www.cnnindonesia.com/nasional/20210302120516-20-612595/dua-kasus-mutasi-corona-asal-inggris-ditemukan-di-indonesia |access-date=2 Maret 2021}}</ref><ref>{{cite news |title=Wamenkes Laporkan 2 Kasus Pertama Mutasi Corona B117 di Indonesia |date=2 Maret 2021 |work=detikHealth |url=https://health.detik.com/berita-detikhealth/d-5477409/wamenkes-laporkan-2-kasus-pertama-mutasi-corona-b117-di-indonesia |access-date=2 Maret 2021}}</ref><ref>{{cite news |author=Jawahir Gustav Rizal |editor=Sari Hardiyanto |date=2 Maret 2021 |title=Mutasi Virus Corona B.1.1.7 Sudah Masuk Indonesia |work=Kompas.com |url=https://www.kompas.com/tren/read/2021/03/02/131116365/mutasi-virus-corona-b117-sudah-masuk-indonesia-ini-informasi-lengkapnya?page=all |access-date=2 Maret 2021}}</ref>
 
=== Garis keturunan B.1.351 (Beta) ===
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=== Garis Keturunan B.1.617 ===
==== Garis Keturunan B.1.617.2 (Delta) ====
'''Varian Delta SARS-CoV-2''', juga dikenal sebagai '''B.1.617.2''',{{efn|Nama lainnya meliputi:<br />– '''G/452R.V3'''<ref>{{cite web |title=COVID-19 Weekly Epidemiological Update (2 May 2021) |url=https://reliefweb.int/sites/reliefweb.int/files/resources/20210504_Weekly_Epi_Update_38.pdf |website=reliefweb.int |publisher=World Health Organization |access-date=6 May 2021}}</ref><br />– '''varian India'''}} adalah sebuah [[Varian SARS-CoV-2|varian]] [[SARS-CoV-2]] [[garis keturunan SARS-CoV-2 B.1.617|bergaris keturunan B.1.617]], [[virus]] yang menyebabkan [https://jnss.eu.org/varian-delta-melonjak-kasus-terbanyak-dki-jakarta/ [COVID-19]].<ref name="gov.uk">{{cite news|url=https://www.gov.uk/government/news/confirmed-cases-of-covid-19-variants-identified-in-uk |title=Confirmed cases of COVID-19 variants identified in UK |website=www.gov.uk |date=15 April 2021 |access-date=2021-04-20}} {{OGL-attribution|version=3.0}}</ref> Varian tersebut dinamai varian Delta oleh WHO melalui sistem penamaan baru yang diperkenalkan pada 31 Mei 2021.<ref name=BBC.May.31.2021>{{cite news |title=Covid: WHO renames UK and other variants with Greek letters |url=https://www.bbc.com/news/world-57308592 |date=2021-05-31 |website=BBC News |access-date=2021-06-08}}</ref> Varian tersebut pertama kali terdeteksi di India pada akhir 2020.<ref name="GISAID">{{cite web |url=https://www.gisaid.org/hcov19-variants/ |title=Tracking of Variants |author=<!--Not stated--> |date=26 April 2021 |website=gisaid.org |publisher=[[GISAID]] |access-date=30 May 2021}}</ref><ref name="SMC1">{{cite web |title=Expert reaction to cases of variant B.1.617 (the 'Indian variant') being investigated in the UK |url=https://www.sciencemediacentre.org/expert-reaction-to-cases-of-variant-b-1-617-the-indian-variant-being-investigated-in-the-uk/ |website=Science Media Centre |access-date=20 April 2021}}</ref>
 
Varian ini bertanggung jawab terhadap sebagian peningkatan kasus pada [[Pandemi COVID-19 di India|gelombang kedua pandemi di India]] yang dimulai sejak Februari 2021.<ref name=":0">[https://www.cnbc.com/2021/05/11/india-covid-explainer-what-we-know-about-the-bpoint1point617-variant.html WHO labels a Covid strain in India as a ‘variant of concern’ — here’s what we know], CNBC, 11 May 2021.</ref><ref name=":1">[https://www.bbc.co.uk/news/world-asia-india-57067190 WHO says India Covid variant of 'global concern'], BBC News, 11 May 2021.</ref><ref>[https://science.thewire.in/health/covid-19-the-second-wave-may-not-be-the-last-but-which-one-will-be/ India’s second COVID-19 wave], The Wire Science, 22 April 2021.</ref>