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|rowspan=2|{{flagicon|DEU}} [[Prüstel GP|CFMoto Racing Prüstel GP]]
!rowspan=2|[[{{ill|CFMoto]]|fr|CFMoto}}
|rowspan=2|[[KTM RC250GP#CFMoto|TBA]]
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|{{flagicon|ESP}} [[Xavier Artigas]]<ref name="Prustel">{{Cite web|date=5 November 2021|title=CFMOTO mengkonfirmasi rencana Moto3 untuk 2022 dengan Prüstel GP|url=https://www.mcnews.com.au/cfmoto-confirm-moto3-plans-for-2022-with-prustel-gp/|website=MCNews|language=en-GB|access-date=10 November 2021}}</ref>
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|{{flagicon|AUS}} [[Joel Kelso]]<ref name="Kelso">{{Cite web|last=Sports|first=Dorna|title=Joel Kelso dari Australia bergabung dengan CIP Green Power untuk 2022|url=https://www.motogp.com/en/news/2021/09/08/australia-s-joel-kelso-joins-cip-green-power-for-2022/389864|access-date=9 September 2021|website=www.motogp.com|language=en}}</ref>
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=== Team changes ===
* [[Sepang Racing Team|Petronas SRT]] willakan withdrawmenarik fromdiri thedari categorykategori atpada theakhir end of themusim 2021 seasonsetelah followingkehilangan thesponsor lossmereka. ofTim theirakan sponsor.melanjutkan Thedi teambawah willmanajemen continueyang undersama thedan samesponsor managementyang andberbeda differentdi sponsor in thekelas [[Grand Prix motorcycle racing|MotoGP]] class.<ref name=":72">{{Cite web|title=SRT quitsmundur dari MotoGP, announcementpengumuman oftim newbaru teamakan duedigelar atdi Misano|url=https://www.motorsport.com/motogp/news/srt-quits-motogp-announcement-of-new-team-due-at-misano/6653934/|access-date=26 AugustAgustus 2021|website=www.motorsport.com|language=en}}</ref>
* ATim newInggris British teambaru, rundijalankan byoleh formermantan riderpembalap [[Michael Laverty]], willakan joinbergabung thedengan championshipkejuaraan withdengan thetujuan aimmemberikan ofbatu providingloncatan Britishkepada riderspembalap withInggris auntuk steppingmemulai stonekejuaraan intodunia the world championship starting from thedari British Talent Cup whichyang wasdidirikan establishedpada intahun 2018. TheTim teamini willakan bedisponsori sponsored byoleh VisionTrack, anddan arediharapkan expectedmengambil toalih takesepeda over themotor Honda bikesyang vacateddikosongkan byoleh thetim [[Sepang Racing Team|Petronas SRT]] team.
* Gresini Racing, whoyang haveberlaga competed fromdari 2012 untilhingga 2021, will leaveakan themeninggalkan championshipkejuaraan tountuk focusfokus onpada theirtim Moto2 anddan MotoGP teamsmereka.
* TeamTim MTA, whichyang hastelah competedberkompetisi in thedi CIV sincesejak 2017 and thedan CEV sincesejak 2019, willakan makekembali theirke returnKejuaraan to theDunia Moto3 World Championship withbersama KTM. TheTim teamtersebut previouslysebelumnya competedberkompetisi indi theKejuaraan Dunia Moto3 World Championship fromdari 2014 tohingga 2016 assebagai "TeamTim Italia", usingmenggunakan Mahindrasepeda bikesMahindra.<ref name="MTAItalia">{{Cite web|title=HistorySejarah|url=https://www.mtaitalia.com/en/about-us/|access-date=30 AugustAgustus 2021|website=www.mtaitalia.com|language=en}}</ref>
* Prüstel GP switchedberalih fromdari actualmesin KTM machinesyang tosebenarnya CFMoto-rebrandedke sepeda KTM bikesbermerek CFMoto.<ref>{{Cite web|url=https://www.gpone.com/en/2021/09/24/moto3/from-china-with-fervor-cf-moto-debuts-in-the-2022-moto3-world-championship.html|title=FromDari China withdengan fervorsemangat: CF Moto debutsdebut indi theKejuaraan 2022Dunia Moto3 World Championship2022|website=GPone.com}}</ref>
*[[Esponsorama Racing|Esponsorama]] juga beralih ke mesin KTM bermerek [[Qianjiang Motorcycle|QJmotor]].<ref>{{Cite web|last=Barstow|first=Ollie|last2=|first2=|date=5 Januari 2022|title=QJ Motor akan menjadi merek keenam yang bergabung dengan grid Moto3 2022|url=https://www.visordown.com/news/racing/motogp/qj-motor-set-become-sixth-brand-join-2022-moto3-grid|url-status=live|access-date=8 Januari 2022|website=Visordown|language=en|archive-url=https://web.archive.org/web/20220105183631/https://www.visordown.com/news/racing/motogp/qj-motor-set-become-sixth-brand-join-2022-moto3-grid |archive-date=5 Januari 2022}}</ref>
=== Rider changes ===
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