De Vries akan membalap untuk [[Scuderia AlphaTauri]] untuk musim {{F1|2023}}, menggantikan [[Pierre Gasly]] yang pindah ke Alpine.<ref name=":0">{{Cite web|last=Cooper|first=Adam|date=8 Oktober 2022|title=De Vries lands full-time F1 drive with AlphaTauri for 2023|url=https://www.motorsport.com/f1/news/f1-nyck-de-vries-alphatauri-drive-for-2023/10381099/|website=www.motorsport.com|language=en|access-date=2022-10-11}}</ref> Pada balapan pertamanya, yaitu {{F1GP|2023|Bahrain}}, de Vries memulai balapan dari posisi ke-19. Ia finis di posisi ke-14, 3 posisi di belakang rekan setimnya.<ref>{{Cite web|date=5 Maret 2023|title=2023 Bahrain Grand Prix race report and highlights: Verstappen leads 1-2 in Bahrain season opener as Leclerc retires and Alonso takes final podium place in style {{!}} Formula 1®|url=https://www.formula1.com/en/latest/article.verstappen-leads-1-2-in-bahrain-season-opener-as-leclerc-retires-and-alonso.40788dU0VkiLz0gxRPo7n1.html|website=www.formula1.com|language=en|access-date=2023-03-18}}</ref>
