Duloksetin: Perbedaan antara revisi

'''Duloxetine''' adalah obat yang digunakan untuk mengatasi [[gangguan depresi mayor]], [[Gangguan kecemasan menyeluruh|gangguan kecemasan umum]], [[fibromyalgia]], dan nyeri neuropatik . <ref name="AHFS2018">{{Cite web|title=Duloxetine|url=https://www.drugs.com/monograph/duloxetine.html|website=Monograph|publisher=The American Society of Health-System Pharmacists|archive-url=https://web.archive.org/web/20181126162525/https://www.drugs.com/monograph/duloxetine.html|archive-date=2018-11-26|access-date=2018-12-24|url-status=live}}</ref> Rute pemberian obat digunakan melalui oral. <ref name="AHFS2018">{{cite web | title = Duloxetine | work = Monograph | url = https://www.drugs.com/monograph/duloxetine.html | publisher = The American Society of Health-System Pharmacists | access-date = 2018-12-24 | archive-date = 2018-11-26 | archive-url = https://web.archive.org/web/20181126162525/https://www.drugs.com/monograph/duloxetine.html | url-status = live }}</ref>

Kemunculan efek samping yang umum terjadi seperti [[Xerostomia|mulut kering]], rasa mual, rasa lelah, rasa pusing, agitasi, gangguan masalah seksual, dan meningkatnya jumlah keringat. <ref name="AHFS2018">{{Cite web|title=Duloxetine|url=https://www.drugs.com/monograph/duloxetine.html|website=Monograph|publisher=The American Society of Health-System Pharmacists|archive-url=https://web.archive.org/web/20181126162525/https://www.drugs.com/monograph/duloxetine.html|archive-date=2018-11-26|access-date=2018-12-24|url-status=live}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/duloxetine.html "Duloxetine"]. ''Monograph''. The American Society of Health-System Pharmacists. [https://web.archive.org/web/20181126162525/https://www.drugs.com/monograph/duloxetine.html Archived] from the original on 2018-11-26<span class="reference-accessdate">. Retrieved <span class="nowrap">2018-12-24</span></span>.</cite></ref> Kemunculan efek samping yang parah seperti meningkatnya risiko ingin [[bunuh diri]], [[sindrom serotonin]], [[mania]], dan masalah hati . <ref name="AHFS2018">{{cite web | title = Duloxetine | work = Monograph | url = https://www.drugs.com/monograph/duloxetine.html | publisher = The American Society of Health-System Pharmacists | access-date = 2018-12-24 | archive-date = 2018-11-26 | archive-url = https://web.archive.org/web/20181126162525/https://www.drugs.com/monograph/duloxetine.html | url-status = live }}</ref> Sindrom penarikan antidepresan bisa terjadi jika penggunaan obat ini dihentikan secara tiba-tiba. <ref name="AHFS2018">{{cite web | title = Duloxetine | work = Monograph | url = https://www.drugs.com/monograph/duloxetine.html | publisher = The American Society of Health-System Pharmacists | access-date = 2018-12-24 | archive-date = 2018-11-26 | archive-url = https://web.archive.org/web/20181126162525/https://www.drugs.com/monograph/duloxetine.html | url-status = live }}</ref> Penggunaan untuk ibu [[Kehamilan|hamil]] berpotensi membahayakan bayi. <ref name="AHFS2018">{{cite web | title = Duloxetine | work = Monograph | url = https://www.drugs.com/monograph/duloxetine.html | publisher = The American Society of Health-System Pharmacists | access-date = 2018-12-24 | archive-date = 2018-11-26 | archive-url = https://web.archive.org/web/20181126162525/https://www.drugs.com/monograph/duloxetine.html | url-status = live }}</ref> Obat ini merupakan inhibitor reuptake serotonin-norepinefrin . <ref name="BNF76">{{Cite book|date=2018|title=British national formulary : BNF 76|publisher=Pharmaceutical Press|isbn=9780857113382|edition=76|pages=364–365}}</ref> Mekanisme kerjanya masih belum diketahui sepenuhnya secara jelas. <ref name="AHFS2018">{{cite web | title = Duloxetine | work = Monograph | url = https://www.drugs.com/monograph/duloxetine.html | publisher = The American Society of Health-System Pharmacists | access-date = 2018-12-24 | archive-date = 2018-11-26 | archive-url = https://web.archive.org/web/20181126162525/https://www.drugs.com/monograph/duloxetine.html | url-status = live }}</ref>