Noretisteron: Perbedaan antara revisi

| caption = [[Lintasan metabolisme]] yang terlibat dalam metabolisme noretisteron pada manusia. Noretisteron asetat, N

Noretisteron enantat, etinodiol, etinodiol diasetat, [[linestrenol]], noretinodrel, kuingestanol, dan kuingestanol asetat semuanya merupakan [[bakal obat]] dari noretisteron. [[Etinilestradiol]] adalah metabolit estrogenik noretisteron yang dibentuk oleh enzim [[sitokrom P450]]. Dua [[isomer]] dihidronoretisteron dan empat isomer tetrahidronoretisteron dibentuk oleh 5α- dan 5β-reduktase serta 3α- dan 3β-hidroksisteroid dehidrogenase dan aktivitasnya berkurang atau tidak ada. Noretisteron dan metabolitnya juga mengalami [[hidroksilasi]] melalui enzim sitokrom P450 dan konjugasi melalui glukuronidasi dan [[sulfasi]] pada [[gugus fungsi]] [[hidroksil]] (–OH) yang tersedia. ''Sumber'':<ref name="Thijssen1972">{{cite book | vauthors = Thijssen JH | chapter = Metabolism of Orally Active Synthetic Progestational Compounds | pages = 217–273 | veditors = Tausk M | title = Pharmacology of the Endocrine System and Related Drugs: Progesterone, Progestational Drugs and Antifertility Agents | volume = II | url = https://books.google.com/books?id=Nv5sAAAAMAAJ | date = September 1972 | publisher = Pergamon Press | isbn = 978-0080168128 | oclc = 278011135}}</ref><ref name="Okada2010">{{cite journal| vauthors = Okada H |title=Receptors and Mechanism Action of Synthetic Progestogens|journal=Asia-Oceania Journal of Obstetrics and Gynaecology|volume=7|issue=1|year=2010|pages=15–27|issn=0389-2328|doi=10.1111/j.1447-0756.1981.tb00511.x}}</ref><ref name="Briggs1980">{{cite book| vauthors = Briggs MH |title=Clinical Pharmacology & Therapeutics|chapter=Comparative Pharmacodynamics and Pharmacokinetics of Contraceptive Steroids in Animals and Man: A Selective Review|year=1980|pages=493–518|publisher=Palgrave Macmillan UK |doi=10.1007/978-1-349-05952-2_57|isbn=978-1-349-05954-6}}</ref><ref name="ThomasKeenan1986">{{cite book| vauthors = Thomas JA, Keenan EJ |chapter=Progestins and Oral Contraceptives|title=Principles of Endocrine Pharmacology|year=1986|pages=167–196|publisher=Springer |doi=10.1007/978-1-4684-5036-1_8|isbn=978-1-4684-5036-1}}</ref><ref name="pmid6342899">{{cite journal | vauthors = Orme ML, Back DJ, Breckenridge AM | title = Clinical pharmacokinetics of oral contraceptive steroids | journal = Clinical Pharmacokinetics | volume = 8 | issue = 2 | pages = 95–136 | date = 1983 | pmid = 6342899 | doi = 10.2165/00003088-198308020-00001 | s2cid = 43298472 }}</ref><ref name="pmid4206183">{{cite journal | vauthors = Fotherby K | title = Metabolism of synthetic steroids by animals and man | journal = Acta Endocrinologica. Supplementum | volume = 185 | pages = 119–147 | date = 1974 | pmid = 4206183 | doi = 10.1530/acta.0.075s119 }}</ref><ref name="pmid2170822">{{cite journal | vauthors = Kuhl H | title = Pharmacokinetics of oestrogens and progestogens | journal = Maturitas | volume = 12 | issue = 3 | pages = 171–197 | date = September 1990 | pmid = 2170822 | doi = 10.1016/0378-5122(90)90003-o }}</ref><ref name="Kuhl2011" /><ref name="pmid16112947" /><ref name="pmid17653961">{{cite journal | vauthors = Kuhl H, Wiegratz I | title = Can 19-nortestosterone derivatives be aromatized in the liver of adult humans? Are there clinical implications? | journal = Climacteric | volume = 10 | issue = 4 | pages = 344–353 | date = August 2007 | pmid = 17653961 | doi = 10.1080/13697130701380434 | s2cid = 20759583 }}</ref><ref name="StanczykRoy1990">{{cite journal | vauthors = Stanczyk FZ, Roy S | title = Metabolism of levonorgestrel, norethindrone, and structurally related contraceptive steroids | journal = Contraception | volume = 42 | issue = 1 | pages = 67–96 | date = July 1990 | pmid = 2143719 | doi = 10.1016/0010-7824(90)90093-B }}</ref>

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