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==Penelitian==
Investigasi eksperimental pada TZD telah dilakukan sejak tahun 2005 pada [[sindrom ovarium polikistik]] (PCOS), steatohepatitis[[penyakit perlemakan hati non-alkoholalkoholik]] (NASH),<ref name=NASH>{{cite journal | vauthors = Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, Balas B, Gastaldelli A, Tio F, Pulcini J, Berria R, Ma JZ, Dwivedi S, Havranek R, Fincke C, DeFronzo R, Bannayan GA, Schenker S, Cusi K | display-authors = 6 | title = A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis | journal = The New England Journal of Medicine | volume = 355 | issue = 22 | pages = 2297–2307 | date = November 2006 | pmid = 17135584 | doi = 10.1056/NEJMoa060326 | doi-access = free }}</ref><ref>{{ClinicalTrialsGov|NCT00227110|Role of Pioglitazone in the Treatment of Non-alcoholic Steatohepatitis (NASH)}}</ref> [[psoriasis]],<ref>{{cite journal | vauthors = Krentz AJ, Friedmann PS | title = Type 2 diabetes, psoriasis and thiazolidinediones | journal = International Journal of Clinical Practice | volume = 60 | issue = 3 | pages = 362–363 | date = March 2006 | pmid = 16494655 | doi = 10.1111/j.1368-5031.2005.00765.x | s2cid = 34287396 | doi-access = free }}</ref> [[autisme]],<ref>{{cite journal | vauthors = Boris M, Kaiser CC, Goldblatt A, Elice MW, Edelson SM, Adams JB, Feinstein DL | title = Effect of pioglitazone treatment on behavioral symptoms in autistic children | journal = Journal of Neuroinflammation | volume = 4 | pages = 3 | date = January 2007 | pmid = 17207275 | pmc = 1781426 | doi = 10.1186/1742-2094-4-3 | doi-access = free }}</ref> sindrom hiperstimulasi ovarium (oleh penghambatan VEGF pada [[sel granulosa]]),<ref>{{cite journal | vauthors = Shah DK, Menon KM, Cabrera LM, Vahratian A, Kavoussi SK, Lebovic DI | title = Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro | journal = Fertility and Sterility | volume = 93 | issue = 6 | pages = 2042–2047 | date = April 2010 | pmid = 19342033 | pmc = 2847675 | doi = 10.1016/j.fertnstert.2009.02.059 }}</ref> lichen planopilaris, dan kondisi lainnya.<ref name=trials>[http://clinicaltrials.gov/ct/search?term=rosiglitazone&submit=Search Clinical Trials for Rosiglitazone] – from ClinicalTrials.gov, a service of the U.S. [[National Institutes of Health]]{{verify source|should point to a specific page and not a list of search results|date=March 2015}}</ref>
Bukti muncul pada tahun 2008 bahwa [[vitamin E]] dengan tiazolidinediontiazolidindion efektif dalam pengobatan steatohepatitispenyakit perlemakan hati non-alkoholalkoholik karena efek antioksidan dan sensitisasi insulin gabungannya, menghasilkan perbaikan histologis dalam tingkat keparahan steatosis.<ref>{{cite journal | vauthors = Chitturi S | title = Treatment options for nonalcoholic Fatty liver disease | journal = Therapeutic Advances in Gastroenterology | volume = 1 | issue = 3 | pages = 173–189 | date = November 2008 | pmid = 21180527 | pmc = 3002502 | doi = 10.1177/1756283X08096951 }}</ref>
TiazolindinedionTiazolindindion menginduksi adipogenesis pada timbunan lemak subkutan dengan mengaktifkan reseptor ''PPARγ''.<ref>{{cite journal |last1=Alser |first1=Maha |last2=Elrayess |first2=Mohamed A. |title=From an Apple to a Pear: Moving Fat around for Reversing Insulin Resistance |journal=International Journal of Environmental Research and Public Health |date=January 2022 |volume=19 |issue=21 |pages=14251 |doi=10.3390/ijerph192114251 |doi-access=free |pmid=36361131 |pmc=9659102|issn=1660-4601}}</ref> Efek ini telah digunakan pada pasien [[transgender]] untuk menggeser distribusi lemak tubuh ke arah pola yang lebih ginoid.<ref>{{cite journal |last1=Malik |first1=I. |last2=Barrett |first2=J. |last3=Seal |first3=L. |title=Thiazolindinediones are useful in achieving female type fat distribution in male to female transsexuals |journal=Endocrine Abstracts |date=1 March 2009 |volume=19 |url=https://www.endocrine-abstracts.org/ea/0019/ea0019p74# |access-date=27 April 2024|issn=1470-3947}}</ref>
==Efek samping dan kontraindikasi==
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