|
==Kegunaan dalam medis==
===Suntikan intra-artikular===
DigunakanNatrium hialurinat digunakan untuk mengobati nyeri lutut pada pasien osteoartritis yang belum sembuh dari pengobatan lain. DisuntikkanJuga disuntikkan ke kapsul sendi, untuk bertindak sebagai peredam kejut dan pelumas sendi.[3][4][<ref>{{cite web|title=Hyaluronate sodium: Indications, Side Effects, Warnings|url=https://www.drugs.com/cdi/hyaluronate-sodium.html|work=Drugs.com|access-date=25 February 2014|format=Web|date=5] February 2014}}</ref><ref name="Bannuru">{{cite journal | vauthors = Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE | title = Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis | journal = Annals of Internal Medicine | volume = 162 | issue = 1 | pages = 46–54 | date = January 2015 | pmid = 25560713 | doi = 10.7326/M14-1231 | s2cid = 207538194 }}</ref><ref name="Mandl">{{cite journal | vauthors = Mandl LA, Losina E | title = Relative efficacy of knee osteoarthritis treatments: are all placebos created equal? | journal = Annals of Internal Medicine | volume = 162 | issue = 1 | pages = 71–72 | date = January 2015 | pmid = 25560716 | pmc = 4545522 | doi = 10.7326/M14-2636 }}</ref> Jadi natrium hialuronat digunakan sebagai viskosuplemen, diberikan melalui serangkaian suntikan ke lutut, meningkatkan [[kekentalan|viskositas]] [[cairan sinovial,]] yang membantu melumasi, meredam, dan mengurangi nyeri sendi.[6]<ref name = "pmid9486013">{{cite journal | vauthors = Puhl W, Scharf P | title = Intra-articular hyaluronan treatment for osteoarthritis | journal = Annals of the Rheumatic Diseases | volume = 56 | issue = 7 | pages = 441 | date = July 1997 | pmid = 9486013 | pmc = 1752402 | doi = 10.1136/ard.56.7.441 }}</ref> Umumnya digunakan sebagai pilihan terakhir sebelum operasi[7]pembedahan<ref name=pmid12421996>{{cite journal | vauthors = Karlsson J, Sjögren LS, Lohmander LS | title = Comparison of two hyaluronan drugs and placebo in patients with knee osteoarthritis. A controlled, randomized, double-blind, parallel-design multicentre study | journal = Rheumatology | volume = 41 | issue = 11 | pages = 1240–1248 | date = November 2002 | pmid = 12421996 | doi = 10.1093/rheumatology/41.11.1240 | doi-access = free }}</ref> dan memberikan kelegaan simtomatik, dengan memulihkan viskoelastisitas cairan sendi, dan dengan merangsang produksi baru cairan sinovial.[2]<ref name = "pmid12918884" >{{cite journal | vauthors = Jubb RW, Piva S, Beinat L, Dacre J, Gishen P | title = A one-year, randomised, placebo (saline) controlled clinical trial of 500-730 kDa sodium hyaluronate (Hyalgan) on the radiological change in osteoarthritis of the knee | journal = International Journal of Clinical Practice | volume = 57 | issue = 6 | pages = 467–474 | year = 2003 | pmid = 12918884 | doi = 10.1111/j.1742-1241.2003.tb10535.x | s2cid = 28214461 }}</ref> Penggunaan natrium hialuronat dapat mengurangi kebutuhan penggantian sendi.[8]<ref>{{cite journal | vauthors = Kotz R, Kolarz G | title = Intra-articular hyaluronic acid: duration of effect and results of repeated treatment cycles | journal = American Journal of Orthopedics | volume = 28 | issue = 11 Suppl | pages = 5–7 | date = November 1999 | pmid = 10587245 }}</ref> Suntikan tampaknya meningkatkan efektivitas selama empat minggu, mencapai puncaknya pada delapan minggu dan mempertahankan sebagian efektivitas pada enam bulan, dengan manfaat yang lebih besar untuk osteoartritis daripada [[analgesik]] oral.[9]<ref name=pmid21443958>{{cite journal | vauthors = Bannuru RR, Natov NS, Dasi UR, Schmid CH, McAlindon TE | title = Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis--meta-analysis | journal = Osteoarthritis and Cartilage | volume = 19 | issue = 6 | pages = 611–619 | date = June 2011 | pmid = 21443958 | doi = 10.1016/j.joca.2010.09.014 | doi-access = free }}</ref> Mungkin juga efektif bila digunakan pada sendi pergelangan kaki.[<ref name=pmid16452740>{{cite journal | vauthors = Salk RS, Chang TJ, D'Costa WF, Soomekh DJ, Grogan KA | title = Sodium hyaluronate in the treatment of osteoarthritis of the ankle: a controlled, randomized, double-blind pilot study | journal = The Journal of Bone and Joint Surgery. American Volume | volume = 88 | issue = 2 | pages = 295–302 | date = February 2006 | pmid = 16452740 | doi = 10].2106/JBJS.E.00193 }}</ref>
===Injeksi viskoelastis intraokular===
|
