Iksabepilon: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
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Tidak ada ringkasan suntingan Tag: Suntingan perangkat seluler Suntingan peramban seluler Suntingan seluler lanjutan |
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==Farmakologi==
Seperti [[paklitaksel]], iksabepilon bertindak untuk menstabilkan [[mikrotubulus]].<ref>{{cite journal | vauthors = Lopus M, Smiyun G, Miller H, Oroudjev E, Wilson L, Jordan MA | title = Mechanism of action of ixabepilone and its interactions with the βIII-tubulin isotype | journal = Cancer Chemotherapy and Pharmacology | volume = 76 | issue = 5 | pages = 1013–1024 | date = November 2015 | pmid = 26416565 | doi = 10.1007/s00280-015-2863-z | s2cid = 1842156 }}</ref><ref name="pmid18321240">{{cite journal | vauthors = Denduluri N, Swain SM | title = Ixabepilone for the treatment of solid tumors: a review of clinical data | journal = Expert Opinion on Investigational Drugs | volume = 17 | issue = 3 | pages = 423–435 | date = March 2008 | pmid = 18321240 | doi = 10.1517/13543784.17.3.423 | s2cid = 71169099 }}</ref><ref name="pmid18945860">{{cite journal | vauthors = Goodin S | title = Ixabepilone: a novel microtubule-stabilizing agent for the treatment of metastatic breast cancer | journal = American Journal of Health-System Pharmacy | volume = 65 | issue = 21 | pages = 2017–2026 | date = November 2008 | pmid = 18945860 | doi = 10.2146/ajhp070628 }}</ref> Obat ini sangat kuat, mampu merusak sel kanker dalam konsentrasi yang sangat rendah, dan mempertahankan aktivitas dalam kasus di mana sel tumor tidak sensitif terhadap obat jenis taksana.<ref name="pancreas">{{cite journal | vauthors = Vulfovich M, Rocha-Lima C | title = Novel advances in pancreatic cancer treatment | journal = Expert Review of Anticancer Therapy | volume = 8 | issue = 6 | pages = 993–1002 | date = June 2008 | pmid = 18533808 | doi = 10.1586/14737140.8.6.993 | s2cid = 20049942 }}</ref>
==Persetujuan==
==Kegunaan klinis==
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