Kuinidin: Perbedaan antara revisi
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==Farmakologi==
===Farmakodinamik===
Kuinidin bekerja sebagai penghambat saluran natrium berpagar tegangan.<ref name="pmid25927480">{{cite journal | vauthors = de Lera Ruiz M, Kraus RL | title = Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications | journal = Journal of Medicinal Chemistry | volume = 58 | issue = 18 | pages = 7093–7118 | date = September 2015 | pmid = 25927480 | doi = 10.1021/jm501981g | doi-access = free }}</ref><ref name="Abriel2015">{{cite book| vauthors = Roden DM | chapter = Pharmacology and Toxicology of Na<sub>V</sub>1.5 Class 1 Antiarrhythmic Drugs | veditors = Abriel H |title=Cardiac Sodium Channel Disorders, An Issue of Cardiac Electrophysiology Clinics, E-Book| chapter-url = https://books.google.com/books?id=vnKPBQAAQBAJ&pg=PA695|date=1 September 2015|publisher=Elsevier Health Sciences|isbn=978-0-323-32641-4|pages=695–}}</ref> Penghambatan saluran Na<sub>v</sub>1.5 secara khusus terlibat dalam efek antiaritmianya sebagai agen antiaritmia kelas I.<ref name="HemmingsEgan2013">{{cite book | vauthors = Abbott GW, Levi R | chapter = Antiarrhythmic Drugs | veditors = Hemmings HC, Egan TD |title=Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application: Expert Consult - Online and Print| chapter-url=https://books.google.com/books?id=s8CXrbimviMC&pg=PT451|year=2013|publisher=Elsevier Health Sciences|isbn=978-1-4377-1679-5|pages=451–}}</ref> Kuinidin juga menghambat [[saluran kalium]] berpagar tegangan tertentu (misalnya, K<sub>v</sub>1.4, K<sub>v</sub>4.2, hERG, dan lain-lain),<ref name="UrbanPatel2015">{{cite book| vauthors = Pearlstein RA, MacCannell KA, Hu QY, Farid R, Duca JS | chapter = The Mechanistic Basis of hERG Blockade and the Proarrhythmic Effects Thereof | veditors = Urban L, Patel V, Vaz RJ |title=Antitargets and Drug Safety| chapter-url = https://books.google.com/books?id=jkBPCAAAQBAJ&pg=PA303 |date=23 February 2015|publisher=Wiley|isbn=978-3-527-67367-4|pages=303–}}</ref><ref name="ArcherRusch2012">{{cite book | vauthors = Archer SL, Rusch NJ |title=Potassium Channels in Cardiovascular Biology|url=https://books.google.com/books?id=e_gxBwAAQBAJ&pg=PT343|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-1-4615-1303-2|pages=343–}}</ref> bekerja sebagai antimuskarinik dan penghambat alfa-1,<ref name="pmid9570190">{{cite journal | vauthors = Shibata K, Hirasawa A, Foglar R, Ogawa S, Tsujimoto G | title = Effects of quinidine and verapamil on human cardiovascular alpha1-adrenoceptors | journal = Circulation | volume = 97 | issue = 13 | pages = 1227–1230 | date = April 1998 | pmid = 9570190 | doi = 10.1161/01.cir.97.13.1227 | doi-access = free }}</ref> dan juga merupakan antimalaria.<ref name="HemmingsEgan2013" /> Kuinidin juga dikatakan sebagai [[antagonis reseptor]] asetilkolin M<sub>3</sub> muskarinik selektif.<ref name="LavradorCabralVeríssimo2023">{{cite journal | vauthors = Lavrador M, Cabral AC, Veríssimo MT, Fernandez-Llimos F, Figueiredo IV, Castel-Branco MM | title = A Universal Pharmacological-Based List of Drugs with Anticholinergic Activity | journal = Pharmaceutics | volume = 15 | issue = 1 | date = January 2023 | page = 230 | pmid = 36678858 | pmc = 9863833 | doi = 10.3390/pharmaceutics15010230 | doi-access = free | url = }}</ref>
====Mekanisme kerja====
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