'''Leflunomida''' adalah [[obat antirematik pengubahpemodifikasi penyakit imunosupresif]] (DMARD) imunosupresif,<ref name="pmid15271770">{{cite journal | vauthors = Dougados M, Emery P, Lemmel EM, Zerbini CA, Brin S, van Riel P | title = When a DMARD fails, should patients switch to sulfasalazine or add sulfasalazine to continuing leflunomide? | journal = Annals of the Rheumatic Diseases | volume = 64 | issue = 1 | pages = 44–51 | date = January 2005 | pmid = 15271770 | pmc = 1755199 | doi = 10.1136/ard.2003.016709 }}</ref> yang digunakan pada artritis[[rheumatoid reumatoidarthritis]] sedang hingga berat dan artritis psoriatis. Obat ini merupakan penghambat sintesis pirimidin yang bekerja dengan menghambat dihidroorotat dehidrogenase.<ref name="pmid17094333">{{cite journal | vauthors = Pinto P, Dougados M | title = Leflunomide in clinical practice | journal = Acta Reumatologica Portuguesa | volume = 31 | issue = 3 | pages = 215–24 | year = 2006 | pmid = 17094333 | url = http://www.actareumatologica.pt/oldsite/conteudo/pdfs/ARP_2006_4_216_AR_-_Leflunomide.pdf }}</ref>
