Pada 14 Juli 2023, Openda menandatangani kontrak dengan klub [[Fußball-Bundesliga|Bundesliga]] [[RB Leipzig]] dengan kontrak selama lima tahun.<ref>{{Cite web |date=2023-07-14 |title=Done deal! RB Leipzig sign Loïs Openda |url=https://rbleipzig.com/en/news/2023-2024/rb-leipzig-sign-lois-openda/ |archive-url=https://web.archive.org/web/20230714205218/https://rbleipzig.com/en/news/2023-2024/rb-leipzig-sign-lois-openda/ |archive-date=2023-07-14 |access-date= |publisher=[15[RB Leipzig]]}}</ref> Biaya transfer yang dilaporkan berada di kisaran €43 hingga €46 juta, dengan potensi bonus yang bertambah hingga €6 juta.[16]<ref>{{Cite web |last=Barbaud |first=Maxime |date=2023-07-14 |title=Le RB Leipzig met enfin la main sur Loïs Openda |url=https://www.footmercato.net/a5662509221080073447-le-rb-leipzig-met-enfin-la-main-sur-lois-openda |archive-url=https://web.archive.org/web/20231215214111/https://www.footmercato.net/a5662509221080073447-le-rb-leipzig-met-enfin-la-main-sur-lois-openda |archive-date=2023-12-15 |access-date=2023-07-14 |website=Foot Mercato |language=fr}}</ref> Pada 19 Agustus, ia mencetak gol pertamanya pada debut Bundesliga-nya dalam kekalahan 3-2 melawan [[Bayer 04 Leverkusen|Bayer Leverkusen.[17]].<ref>{{cite web |date=19 August 2023 |title=Bayer Leverkusen düpiert RB Leipzig im Duell der Mitfavoriten |url=https://www.ran.de/sports/fussball/bundesliga/news/bayer-leverkusen-rb-leipzig-spielbericht1-spieltag-boniface-openda-316236 |archive-url=https://web.archive.org/web/20231004202100/https://www.ran.de/sports/fussball/bundesliga/news/bayer-leverkusen-rb-leipzig-spielbericht1-spieltag-boniface-openda-316236 |archive-date=4 October 2023 |publisher=Ran |language=de}}</ref> Pada 4 Oktober, ia menjaringkan gol pertamanya di [[Liga Champions Eropa]] dalam kekalahan kandang 1-3 melawan [[Manchester City F.[18C.|Manchester City]].<ref>{{cite web |last=Begley |first=Emlyn |url=https://www.bbc.com/sport/football/66999156 |title=Leipzig 1-3 Manchester City: Substitutes Julian Alvarez and Jeremy Doku help City clinch late win |publisher=BBC Sport |date=4 October 2023 }}</ref> Pada 28 November, Openda mencetak dua gol di [[Stadion City of Manchester]] melawan Manchester City, meskipun timnya kalah 3-2.[19]<ref>{{Cite web |date=28 November 2023 |title=RB Leipzig beaten by Manchester City despite Loïs Openda double |url=https://www.bundesliga.com/en/bundesliga/news/manchester-city-rb-leipzig-live-champions-league-team-news-match-stats-haaland-25412 |archive-url=https://web.archive.org/web/20231212202140/https://www.bundesliga.com/en/bundesliga/news/manchester-city-rb-leipzig-live-champions-league-team-news-match-stats-haaland-25412 |archive-date=12 December 2023 |access-date=2023-11-28 |website=Bundesliga |language=en}}</ref> Ia menyelesaikan musim debut Bundesliga-nya di klub tersebut sebagai pencetak gol terbanyak mereka dengan 24 gol, hanya di belakang [[Harry Kane]] dan [[Serhou Guirassy]] di liga.[20]<ref>{{cite web |last=Sharma |first=Abhinav |url=https://www.goal.com/en/lists/bundesliga-top-scorers-2023-24/blt5cb7bb94f705632b#cs81f35c878297d8df |title=Bundesliga top scorers 2023-24: Harry Kane, Serhou Guirassy & players with the most goals in Germany this season |publisher=Goal.com |date=19 May 2024 }}</ref>
Pada 31 Agustus 2024, Openda mencetak dua gol melawan Bayer Leverkusen untuk mengakhiri rekor tak terkalahkan mereka di Bundesliga untuk pertama kalinya dalam 15 bulan.
