Komponen komplemen 3: Perbedaan antara revisi
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'''Komponen komplemen 3''' ({{lang-en|complement component 3, C3}}) adalah salah satu [[glikoprotein]] dengan panjang 1663 [[asam amino]] yang berperan di dalam [[sistem komplemen]]<ref name="pmid11414361">{{cite journal | author = Sahu A, Lambris JD | title = Structure and biology of complement protein C3, a connecting link between innate and acquired immunity | journal = Immunol. Rev. | volume = 180 | issue = | pages = 35–48 | year = 2001 | month = April | pmid = 11414361 | doi = 10.1034/j.1600-065X.2001.1800103.x | url = }}</ref> yang terkodikasi pada [[kromosom]] 19 pada [[gen]] C3.<ref name="pmid2579379">{{cite journal | author = de Bruijn MH, Fey GH | title = Human complement component C3: cDNA coding sequence and derived primary structure | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 82 | issue = 3 | pages = 708–12 | year = 1985 | month = February | pmid = 2579379 | pmc = 397115 | url = http://www.pnas.org/content/82/3/708.abstract | doi = 10.1073/pnas.82.3.708 }}</ref><ref name = "entrez_718">{{cite web | title = Entrez Gene: C3 complement component 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=718| accessdate = }}</ref>
Aktivasi C3 diperlukan untuk memicu [[lintasan komplemen klasik]] dan [[lintasan komplemen alternatif]]. Kekurangan kadar C3 akan menurunkan [[sistem kekebalan]] terhadap [[infeksi]] [[bakteri
C3 berinteraksi dengan [[faktor komplemen H|faktor H]],<ref name=pmid9291131>{{cite journal | quotes = yes |last=Soames |first=C J |authorlink= |coauthors=Sim R B |year=[[1997]]|month=Sep. |title=Interactions between human complement components factor H, factor I and C3b |journal=Biochem. J. |volume=326 ( Pt 2) |issue= |pages=553–61 |publisher= |location = ENGLAND| issn = 0264-6021| pmid = 9291131 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11367533>{{cite journal | quotes = yes |last=Jokiranta |first=T S |authorlink= |coauthors=Westin J, Nilsson U R, Nilsson B, Hellwage J, Löfås S, Gordon D L, Ekdahl K N, Meri S |year=[[2001]]|month=Mar. |title=Complement C3b interactions studied with surface plasmon resonance technique |journal=Int. Immunopharmacol. |volume=1 |issue=3 |pages=495–506 |publisher= |location = Netherlands| issn = 1567-5769| pmid = 11367533 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> dan [[faktor komplemen B|faktor B]] yang telah teraktivasi oleh [[faktor komplemen D|faktor D]] berupa Bb, menjadi C3Bb, yang disebut C3 konvertase AP.
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[[Kategori:Sistem kekebalan]]
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