Manga ini diadaptasi ke dalam serial televisi [[anime]] oleh studio Bones dan disutradaraididireksi oleh Rie Matsumoto.<ref>{{cite web|url=http://www.animenewsnetwork.com/news/2014-10-30/blood-blockade-battlefront-tv-anime-bones-staff-cast-unveiled/.80492|title=Blood Blockade Battlefront TV Anime's BONES Staff, Cast Unveiled|date=October 30, 2014|accessdate=October 30, 2014|work=[[Anime News Network]]}}</ref><ref name="anime"/> Adaptasi anime ini tayang perdana pada 4 April 2015. Serial ini dilisensi oleh Madman Entertainment dan AnimeLab untuk edisi bahasa Inggris.<ref>{{cite press release|url=https://www.animenewsnetwork.com/press-release/2015-04-08/madman-april-acquisitions/.86854|title=Madman's April Acquisitions.|date=April 7, 2015}}</ref><ref>{{cite web|url=https://www.animenewsnetwork.com/press-release/2015-04-08/madman-april-acquisitions/.86854|title= AnimeLab Announces New Titles for Spring Simulcasts|date=April 8, 2015}}</ref> Anime ini menggunakan 2 lagu tema: lagu tema embuka "Hello, World!" oleh Bump of Chicken dan lagu tema penutup "Sugar Song to Bitter Step" oleh Unison Square Garden.<ref>{{cite web|url=https://www.animenewsnetwork.com/news/2015-04-10/unison-square-garden-performs-blood-blockade-battlefront-anime-ending-theme/.86979|title=Unison Square Garden Performs Blood Blockade Battlefront Anime's Ending Theme|date=April 10, 2015|publisher=Anime News Network}}</ref> Episode terakhir awalnya dijadwalkan pada tanggal 4 Juli,<ref name="final">{{cite web|url=http://www.animenewsnetwork.com/daily-briefs/2015-06-07/delayed-blood-blockade-battlefront-finale-conflicts-with-durarara-x2-season-2-premiere/.89011|title=Delayed Blood Blockade Battlefront Finale Conflicts With Durarara!!x2 Season 2 Premiere |publisher=Anime News Network|accessdate=June 9, 2015}}</ref> namun ditunda karena memiliki panjang yang melebihi durasi normal 30 menit.<ref>{{cite web|url=http://www.animenewsnetwork.com/news/2015-06-30/blood-blockade-battlefront-finale-delayed-until-further-notice/.89880|title=Blood Blockade Battlefront Finale Delayed Until Further Notice|date=June 30, 2015|website=Anime News Network |accessdate=June 30, 2015}}</ref>
