GPR56: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
←Membuat halaman berisi ''''GPR56''' adalah anggota dari ''adhesion GPCR''.<ref>{{cite journal | vauthors = Langenhan T, Aust G, Hamann J | title = Sticky signaling--adhesion class G prote...' |
Tidak ada ringkasan suntingan |
||
Baris 6:
* Kolagen III<ref>{{cite journal | vauthors = Luo R, Jeong SJ, Jin Z, Strokes N, Li S, Piao X | title = G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination | journal = Proc Natl Acad Sci USA | volume = 108 | issue = 31 | pages = 12925-30 | year = 2011 | pmid = 21768377 | pmc = 3150909 | doi = 10.1073/pnas.1104821108}}</ref>
* Heparin<ref>{{cite journal | vauthors = Chiang NY, Chang GW, Huang YS, Peng YM, Hsiao CC, Kuo ML, Lin HH | title = Heparin interacts with the adhesion GPCR GPR56, reduces receptor shedding, and promotes cell adhesion and motility | journal = J Cell Sci. | volume = 129 | issue = 11 | pages = | year = 2016 | pmid = 27068534 | doi = 10.1242/jcs.174458}}</ref>
==Peran GPR56==
GPR56 banyak berperan dalam proses-proses berikut:
* Pembentukan dan penjagaan sel punca hematopoietik
* Perkembangan kortikal
* Kesuburan pria
* Hipertropi otot
* Pertumbuhan dan progesi melanoma
* Reseptor penghambat pada sel NK<ref>{{cite journal | vauthors = Chang GW, Hsiao CC, Peng YM, Vieira Braga FA, Kragten NA, Remmerswaal EB, et al | title = The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells | journal = Cell Rep. | volume = 15 | issue = 8 | pages = 1757-70 | year = 2016 | pmid = 27184850 | doi = 10.1016/j.celrep.2016.04.053}}</ref>
* Menghambat migrasi sel NK baik secara spontan maupun distimulasi SDF-1<ref>{{cite journal | vauthors = Peng YM, van de Garde MD, Cheng KF, Baars PA, Remmerswaal EB, van Lier RA, et al | title = Specific expression of GPR56 by human cytotoxic lymphocytes | journal = J Leukoc Biol. | volume = 90 | issue = 4 | pages = 735-40 | year = 2011 | pmid = 21724806 | doi = 10.1189/jlb.0211092}}</ref>
==Mutasi pada ''GPR56''==
Mutasi pada ''GPR56'' menyebabkan malformasi otak manusia dinamakan ''[[bilateral frontoparietal polymicrogyria]]'' (BFPP).<ref>{{cite journal | vauthors = Piao X, Hill RS, Bodell A, Chang BS, Basel-Vanagaite L, Straussberg R, et al | title = G protein-coupled receptor-dependent development of human frontal cortex | journal = Science | volume = 303 | issue = 5666 | pages = 2033-6 | year = 2004 | pmid = 15044805 | doi = }}</ref>
==Transduksi sinyal==
| |||