GPR56: Perbedaan antara revisi

'''GPR56''' adalah anggota dari [[''adhesion GPCR'']].<ref>{{cite journal | vauthors = Langenhan T, Aust G, Hamann J | title = Sticky signaling--adhesion class G protein-coupled receptors take the stage | journal = Sci Signal. | volume = 6 | issue = 276 | pages = | year = 2007 | pmid = 23695165 | doi = 10.1126/scisignal.2003825}}</ref>

 

Ligan-ligan yang berinteraksi dengan GPR56:

* [[transglutaminse]] 2 (TG2)<ref>{{cite journal | vauthors = Xu L, Begum S, Hearn JD, Hynes RO | title = GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis | journal = Proc Natl Acad Sci USA | volume = 103 | issue = 24 | pages = 9023-8 | year = 2006 | pmid = 16757564 | pmc = 1474142 | doi = }}</ref>

* [[heparin]]<ref>{{cite journal | vauthors = Chiang NY, Chang GW, Huang YS, Peng YM, Hsiao CC, Kuo ML, Lin HH | title = Heparin interacts with the adhesion GPCR GPR56, reduces receptor shedding, and promotes cell adhesion and motility | journal = J Cell Sci. | volume = 129 | issue = 11 | pages = | year = 2016 | pmid = 27068534 | doi = 10.1242/jcs.174458}}</ref>

 

GPR56 diekspresikan pada:

* sel NK CD56^dim manusia

Ekspresi GPR56 diinduksi oleh [[faktor transkripsi]] [[Hobit]] (''homolog of [[Blimp-1]]''). Pada manusia, Hobit diekspresikan pada sel NK dan sel T ''quiescent'', sangat dekat kecocokannya dengan ekspresi GPR56.<ref>{{cite journal | vauthors = Vieira Braga FA, Hertoghs KM, Kragten NA, Doody GM, Barnes NA, Remmerswaal EB, et al | title = Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans | journal = Eur J Immunol. | volume = 45 | issue = 10 | pages = 2945-58 | year = 2015 | pmid = 26179882 | doi = 10.1002/eji.201545650}}</ref>

 

GPR56 banyak berperan dalam proses-proses berikut:

* pembentukan dan penjagaan sel punca hematopoietik

* menghambat migrasi sel NK baik secara spontan maupun distimulasi SDF-1<ref>{{cite journal | vauthors = Peng YM, van de Garde MD, Cheng KF, Baars PA, Remmerswaal EB, van Lier RA, et al | title = Specific expression of GPR56 by human cytotoxic lymphocytes | journal = J Leukoc Biol. | volume = 90 | issue = 4 | pages = 735-40 | year = 2011 | pmid = 21724806 | doi = 10.1189/jlb.0211092}}</ref>

 

Mutasi pada ''GPR56'' menyebabkan malformasi otak manusia dinamakan ''[[bilateral frontoparietal polymicrogyria]]'' (BFPP).<ref name="piao">{{cite journal | vauthors = Piao X, Hill RS, Bodell A, Chang BS, Basel-Vanagaite L, Straussberg R, et al | title = G protein-coupled receptor-dependent development of human frontal cortex | journal = Science | volume = 303 | issue = 5666 | pages = 2033-6 | year = 2004 | pmid = 15044805 | doi = }}</ref>

Ada 13 mutasi berbeda pada pasien BFPP, termasuk 1 delesi, 2 ''splicing'', dan 10 mutasi ''missense''.<ref name="piao" /> Jenis-jenis mutasi:

kedua mutasi ini terjadi pada domain GAIN membuat protein dengan pemecahan terganggu secara dramatis sehingga gagal diangkut ke retikulum endoplasma

 

Molekul sinyal yang terlibat dalam transduksi sinyal GPR56 meliputi:

* Gαq/11<ref>{{cite journal | vauthors = Little KD, Hemler ME, Stipp CS | title = Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association | journal = Mol Biol Cell. | volume = 15 | issue = 5 | pages = 2375-87 | year = 2004 | pmid = 15004227 | pmc = 404030 | doi = }}</ref>

* PKCα

* mTOR

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