Latrofilin: Perbedaan antara revisi

Subfamili LPHN tersusun dari tiga anggota, ''LPHN 1-3''.<ref>Ichtchenko K, Bittner MA, Krasnoperov V, Little AR, Chepurny O, Holz RW et al (1999) A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G- protein-coupled receptors. J Biol Chem 274(9):5491–5498</ref> Tidak seperti LPHN2, LPHN1 dan LPHN3 terekspresi tinggi pada otak zebrafish, rodent, dan manusia.<ref>Harty BL, Krishnan A, Sanchez NE, Schi€oth HB, Monk KR (2015) Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. BMC Genomics 16:62</ref><ref>Sugita S, Ichtchenko K, Khvotchev M, Sudhof TC (1998) alpha-Latrotoxin receptor CIRL/ latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis. J Biol Chem 273(49):32715–32724</ref><ref>Boucard AA, Maxeiner S, Sudhof TC (2014) Latrophilins function as heterophilic cell- adhesion molecules by binding to teneurins: regulation by alternative splicing. J Biol Chem 289(1):387–402</ref> Pada rodent, ekspresi ''Lphn1'' dan ''Lphn3'' adalah tinggi sampai minggu ketiga kelahiran dan kemudian menurun pada dewasa, menunjukkan perannya dalam perkembangan otak pasca-kelahiran.<ref>Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (2000) The calcium- independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. J Biol Chem 275 (42):32387–32390</ref> Berbagai studi telah menunjukkan bahwa LPHN1 dan LPHN3 meregulasi perkembangan dan fungsi sinaptik melalui interaksinya dengan berbagai molekul ''partner'' di antaranya [[neureksin]] (NRX), [[teneutin]] (TEN2), dan [[FLRT]].