Trimetilamina N-oksida: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
+aplikasi laboratorium |
+Trimethilaminuria |
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Baris 54:
TMAO dibiosintesikan dari [[trimetilamina]], yang berasal dari [[kolin]].<ref>{{Cite journal |author1=Baker, J.R. |author2=Chaykin, S. | title = The biosynthesis of trimethylamine-''N''-oxide | journal = [[J. Biol. Chem.]] | date=1 April 1962| volume = 237 | pages = 1309–13 |url = http://www.jbc.org/cgi/content/citation/237/4/1309 | pmid = 13864146 | issue = 4 }}</ref>
== Trimethilaminuria ==
[[Trimethilaminuria]] adalah cacat langka dalam produksi enzim [[flavin mengandung monooksigenase 3]] (''FMO3'').<ref>{{cite journal | author=Treacy, E.P.| title=Mutations of the flavin-containing monooxygenase gene (''FMO3'') cause trimethylaminuria, a defect in detoxication | journal=Human Molecular Genetics | year=1998 | pages=839–45 | volume=7 | issue=5| doi=10.1093/hmg/7.5.839 | pmid=9536088 | display-authors=2 | last2=Akerman | first2=BR | last3=Chow | first3=LM | last4=Youil | first4=R | last5=Bibeau | first5=C | last6=Lin | first6=J | last7=Bruce | first7=AG | last8=Knight | first8=M | last9=Danks | first9=DM}}</ref><ref>{{cite journal |vauthors=Zschocke J, Kohlmueller D, Quak E, Meissner T, Hoffmann GF, Mayatepek E | title=Mild trimethylaminuria caused by common variants in FMO3 gene | journal=Lancet | year=1999 | pages=834–5 | volume=354 | issue=9181 | pmid=10485731 | doi=10.1016/S0140-6736(99)80019-1}}</ref> Mereka yang mengalami trimethilaminuria tidak dapat mengubah trimetilamina turunan [[kolin]] menjadi trimetilamina oksida. Trimethilamina kemudian terakumulasi dan dilepaskan dalam keringat, urin, dan napas seseorang, mengeluarkan bau amis kuat.
== Aplikasi laboratorium ==
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