Alzheimer: Perbedaan antara revisi

Penekanan penelitian Alzeheimer ditujukan untuk diagnosis sebelum gejala-gejala timbul.<ref>{{vcite journal | author = Chong MS, Sahadevan S | title = Preclinical Alzheimer's disease: diagnosis and prediction of progression. | journal = Lancet Neurology | volume = 4 | issue = 9 | pages = 576–9 | date = 1 Sep 2005 | pmid = 16109364 | doi = 10.1016/s1474-4422(05)70168-x | url = http://www.ncbi.nlm.nih.gov/pubmed/16109364 | publisher = [[The Lancet]] | accessdate = 7 April 2014 | last2 = Sahadevan | first2 = S }}</ref> Sejumlah tes bio-kimia telah dapat melakukan deteksi awal. Sebuah tes yang melibatkan [[cerebrospinal fluid]] untuk beta-amyloid atau tau proteins,<ref name="pmid17612711">{{vcite journal | author = Marksteiner J, Hinterhuber H, Humpel C | title = Cerebrospinal Fluid Biomarkers for Diagnosis of Alzheimer's Disease: Beta-amyloid(1–42), Tau, Phospho-tau-181 and Total Protein | journal = Drugs of Today | volume = 43 | issue = 6 | pages = 423–31 | year = 2007 | pmid = 17612711 | doi = 10.1358/dot.2007.43.6.1067341 | month = June }}</ref> keduanya merupakan jumlah tau protein dan phosphorylated tau_181P sebagai konsentrasi protein<ref name=demeyer/><ref>{{vcite2 journal |vauthors=Sui X, Liu J, Yang X |title=Cerebrospinal fluid biomarkers of Alzheimer's disease |journal=Neuroscience Bulletin |volume=30 |issue=2 |pages=233–42 |year=2014 |pmid=24733653 |doi=10.1007/s12264-013-1412-1 |type=Review}}</ref> Mencari protein-protein ini menggunakan [[Lumbar puncture|spinal tap]] dapat memprediksi awal Alzheimer dengan tingkat sensitivitas dan spesifisitas ([[sensitivity and specificity|sensitivity]]) antara 94% hingga 100%.<ref name=demeyer/> Jika digunakan bersamaan dengan teknik pencitraan fungsi syarafsaraf ([[Functional neuroimaging]]), dokter dapat mengidentifikasi pasien dengan kehilangan memori yang mana penyakitnya telah berkembang.<ref name=demeyer>{{vcite journal | author = De Meyer G, Shapiro F, Vanderstichele H, Vanmechelen E, Engelborghs S, De Deyn PP, Coart E, Hansson O, Minthon L, Zetterberg H, Blennow K, Shaw L, Trojanowski JQ | title = Diagnosis-Independent Alzheimer Disease Biomarker Signature in Cognitively Normal Elderly People | journal = Archives of Neurology | volume = 67 | issue = 8 | pages = 949–56 | year = 2010 | pmid = 20697045 | pmc = 2963067 | doi = 10.1001/archneurol.2010.179 | month = August }}</ref>