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Perisai kimia juga melindungi terhadap infeksi. Kulit dan sistem pernapasan mengeluarkan [[peptida antimikroba]] seperti β-defensin.<ref>{{cite journal | author = Agerberth B, Gudmundsson G | title = Host antimicrobial defence peptides in human disease. | journal = Curr Top Microbiol Immunol | volume = 306 | issue = | pages = 67–90 | year = | id = PMID 16909918}}</ref> [[Enzim]] seperti [[lisozim]] dan [[fosfolipase A2]] pada [[air liur]], air mata dan [[air susu ibu]] juga [[antiseptik]].<ref>{{cite journal | author = Moreau J, Girgis D, Hume E, Dajcs J, Austin M, O'Callaghan R | title = Phospholipase A(2) in rabbit tears: a host defense against Staphylococcus aureus. | url=http://www.iovs.org/cgi/content/full/42/10/2347 | journal = Invest Ophthalmol Vis Sci | volume = 42 | issue = 10 | pages = 2347–54 | year = 2001 | id = PMID 11527949}}</ref><ref>{{cite journal | author = Hankiewicz J, Swierczek E | title = Lysozyme in human body fluids. | journal = Clin Chim Acta | volume = 57 | issue = 3 | pages = 205-9 | year = 1974 | id = PMID 4434640}}</ref> Sekresi [[Vagina]] merupakan perisai kimia selama [[menarche]], ketika mereka menjadi agak bersifat asal, sementara [[semen]] memiliki pertahanan dan [[zinc]] untuk membunuh patogen.<ref>{{cite journal | author = Fair W, Couch J, Wehner N | title = Prostatic antibacterial factor. Identity and significance. | journal = Urology | volume = 7 | issue = 2 | pages = 169-77 | year = 1976 | id = PMID 54972}}</ref><ref>{{cite journal | author = Yenugu S, Hamil K, Birse C, Ruben S, French F, Hall S | title = Antibacterial properties of the sperm-binding proteins and peptides of human epididymis 2 (HE2) family; salt sensitivity, structural dependence and their interaction with outer and cytoplasmic membranes of Escherichia coli. | url=http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1223422&blobtype=pdf | journal = Biochem J | volume = 372 | issue = Pt 2 | pages = 473-83 | year = 2003 | id = PMID 12628001}}</ref> Pada [[perut]], [[asam lambung]] dan [[protase]] menyediakan pertahanan kimia yang kuat melawan patogen yang tertelan ketika dimakan.
 
Dalam saluran pencernaan dan sistem genitourinari, [[flora]] [[komensalisme|komensal]] merupakan perisai biologi dengan bersaing dengan patogen untuk makanan dan tempat, dan pada beberapa kasus, dengan mengubah kondisi lingkungan mereka, seperti [[pH]] atau besi yang ada.<ref>{{cite journal | author = Gorbach S | title = Lactic acid bacteria and human health | journal = Ann Med | volume = 22 | issue = 1 | pages = 37–41 | year = 1990 | id = PMID 2109988}}</ref> Hal ini mengurangi kemungkinan bahwa patogen akan menyebabkan penyakit. Namun, sejak kebanyakan [[antibiotik]] mengincar bakteri dan tidak menyerang fungi, antibiotik oral dapat menyebabkan "pertumbuhan lebih" [[fungi]] dan dapat menyebabkan kondisi seperti kandiasis vagina.<ref>{{cite journal | author = Hill L, Embil J | title = Vaginitis: current microbiologic and clinical concepts. | url=http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1490817&blobtype=pdf | journal = CMAJ | volume = 134 | issue = 4 | pages = 321-31 | year = 1986 | id = PMID 3510698}}</ref> Terdapat bukti baik bahwa perkenalan kembali flora [https://www.dailydetoxhacks.com/probiotics-for-women/ [probiotik]], seperti budaya asli [[lactobacillus]] yang ada pada [[yogurt]], menolong mengembalikan keseimbangan kesehatan populasi mikrobial pada infeksi usus anak-anak dan mendorong data pendahuluan pada penelitian [[Gastroenteritis bakterial]], [[radang usus]], [[infeksi saluran urin]] dan infeksi setelah operasi.<ref>{{cite journal |author=Reid G, Bruce A |title=Urogenital infections in women: can probiotics help? |url=httphttps://pmjwww.bmjdailydetoxhacks.com/cgi/content/full/79/934probiotics-for-women/428 |journal=Postgrad Med J |volume=79 |issue=934 |pages=428-32 |year=2003 |pmid=12954951}}</ref><ref>{{cite journal | author = Salminen S, Gueimonde M, Isolauri E | title = Probiotics that modify disease risk | url=http://jn.nutrition.org/cgi/content/full/135/5/1294 | journal = J Nutr | volume = 135 | issue = 5 | pages = 1294–8 | year = 2005 | id = PMID 15867327}}</ref><ref>{{cite journal |author=Reid G, Jass J, Sebulsky M, McCormick J |title=Potential uses of probiotics in clinical practice |journal=Clin Microbiol Rev |volume=16 |issue=4 |pages=658-72 |year=2003 |pmid=14557292}}</ref>
 
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