''Panarion'' memberikan informasi sangat berharga mengenai sejarah agama pada abad ke-4, karena si pengarang menyertakan saduran dari naskah-naskah yang hanya ada padanya, juga karena ia menulis pengamatan pribadinya.<!--Mengenai [[Hieracas]] (''Haer.'', lxvii), ia memperkenalkan suatu sekte aneh dari [[Mesir]] yang dihargai baik untuk karya [[asketisisme]] maupun intelektual. In connection with the [[Meletians]] of Egypt (''Haer.'', lxviii), he has preserved important fragments of contemporary Egyptian history of this movement. With regard to [[Arianism]] (''Haer.'', lxix), if he gives an apocryphal letter of [[Constantine I|Constantine]], he transcribes two letters of [[Arius]]. He is the only one to give us any information concerning the [[Goths|Gothic]] sect of the [[Audians]] (''Haer.'', lxx), as well as the [[Arabia]]n sect of the [[Collyridians]]. He has made use of the lost report of the discussion between Photinus (''Haer.'', lxxi), and [[Basil of Ancyra]]. He has transcribed a very important letter from Bishop [[Marcellus of Ancyra]] (''Haer.'', lxxii) to [[Pope Julius I|Pope Julius]], and fragments of the treatise of [[Acacius of Caesarea]] against Marcellus. With regard to the [[Semiarians]] (''Haer.'', lxxiii), he gives in the Acts of the [[Council of Ancyra]] (358) a letter from Basil of Ancyra and one from [[George of Laodicea]], and the stenographic text of a singular sermon of [[Melitius of Antioch|Melitius]] at the time of his installation at [[Antioch]]. In the chapter dealing with the [[Anomoeanism|Anomeans]] (''Haer.'', lxxvi) he has preserved a [[monograph]] of [[Aetius of Antioch|Aetius]].<ref name="Catholic"/>
-->
Epifanius juga menulis ''Anacephalaeoses'', sebagai sebuah ''epitome'', atau versi pendek, dari ''Panarion''.<ref name="Long"/> [[Augustinus dari Hippo|Augustinus]] menggunakannya sebagai dasar dari tulisannya, ''Contra Omnes Haereses'' (="Melawan semua ajaran sesat").<ref name="Williams"/>
