Minicell: Perbedaan antara revisi

== Penggunaan ==

Sistem minicell digunakan secara luas pada akhir 1960-an hingga 1970-an untuk mempelajari berbagai proses termasuk [[pembelahan sel]], transportasi molekul, infeksi [[bakteriofag]], dan sintesis [[polipeptida]].<ref name=":0" /> Sekarang, terdapat minat baru dalam mengembangkan minicell ke dalam sistem penghantaran obat<ref>{{Cite journal|last=MacDiarmid|first=Jennifer A.|last2=Mugridge|first2=Nancy B.|last3=Weiss|first3=Jocelyn C.|last4=Phillips|first4=Leo|last5=Burn|first5=Adam L.|last6=Paulin|first6=Richard P.|last7=Haasdyk|first7=Joel E.|last8=Dickson|first8=Kristie-Ann|last9=Brahmbhatt|first9=Vatsala N.|date=2007-5|title=Bacterially derived 400 nm particles for encapsulation and cancer cell targeting of chemotherapeutics|url=https://www.ncbi.nlm.nih.gov/pubmed/17482133|journal=Cancer Cell|volume=11|issue=5|pages=431–445|doi=10.1016/j.ccr.2007.03.012|issn=1535-6108|pmid=17482133}}</ref><ref>{{Cite journal|last=Lee|first=Jin-Young|last2=Choy|first2=Hyon E.|last3=Lee|first3=Jin-Ho|last4=Kim|first4=Geun-Joong|date=2015-4|title=Generation of Minicells from an Endotoxin-Free Gram-Positive Strain Corynebacterium glutamicum|url=https://www.ncbi.nlm.nih.gov/pubmed/25341464|journal=Journal of Microbiology and Biotechnology|volume=25|issue=4|pages=554–558|issn=1738-8872|pmid=25341464}}</ref> dan [[vaksin]]<ref>{{Cite journal|last=Carleton|first=Heather A.|last2=Lara-Tejero|first2=María|last3=Liu|first3=Xiaoyun|last4=Galán|first4=Jorge E.|date=2013|title=Engineering the type III secretion system in non-replicating bacterial minicells for antigen delivery|url=https://www.ncbi.nlm.nih.gov/pubmed/23481398|journal=Nature Communications|volume=4|pages=1590|doi=10.1038/ncomms2594|issn=2041-1723|pmc=PMC3693737|pmid=23481398}}</ref> yang mengaktifkan respons imun, karena minicell sering mempertahankan sifat virulensi sel induk tetapi tidak dapat berkembang biak.<ref>{{Cite journal|last=Hale|first=T. L.|last2=Sansonetti|first2=P. J.|last3=Schad|first3=P. A.|last4=Austin|first4=S.|last5=Formal|first5=S. B.|date=1983-4|title=Characterization of virulence plasmids and plasmid-associated outer membrane proteins in Shigella flexneri, Shigella sonnei, and Escherichia coli|url=https://www.ncbi.nlm.nih.gov/pubmed/6299962|journal=Infection and Immunity|volume=40|issue=1|pages=340–350|issn=0019-9567|pmc=PMC264854|pmid=6299962}}</ref> Hal terpenting, sifat unik mereka menekankan potensi penggunaan minicell dan mutan penghasil minicell sebagai alat untuk biologi struktural ''in situ''.<ref>{{Cite journal|last=Farley|first=Madeline M.|last2=Hu|first2=Bo|last3=Margolin|first3=William|last4=Liu|first4=Jun|date=2016-4|title=Minicells, Back in Fashion|url=https://www.ncbi.nlm.nih.gov/pubmed/26833418|journal=Journal of Bacteriology|volume=198|issue=8|pages=1186–1195|doi=10.1128/JB.00901-15|issn=1098-5530|pmc=PMC4859596|pmid=26833418}}</ref>