Alprazolam: Perbedaan antara revisi
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k Bot: Perubahan kosmetika |
penambahan infobox Alprazolam |
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{{Infobox drug
| Watchedfields = changed
| verifiedrevid = 477164519
| IUPAC_name = 8-Chloro-1-methyl-6-phenyl-4''H''-[1,2,4]triazolo[4,3-a] [1,4]benzodiazepine
| image = Alprazolam structure.svg
| width = 135
| image2 = Alprazolam ball-and-stick model.png
<!--Clinical data-->| tradename = Xanax, Xanor, Niravam, others
| Drugs.com = {{drugs.com|monograph|alprazolam}}
| pronounce = Alprazolam {{IPAc-en|æ|l|'|p|r|æ|z|ə|l|æ|m}} or {{IPAc-en|æ|l|'|p|r|eɪ|z|ə|l|æ|m}}, Xanax {{IPAc-en|'|z|æ|n|æ|k|s}}
| MedlinePlus = a684001
| DailyMedID = Alprazolam
| pregnancy_US = D
| legal_AU = S8
| legal_CA = Schedule IV
| legal_UK = Class C
| legal_US = Schedule IV
| legal_UN = Psychotropic Schedule IV
| legal_DE = Resep saja/Anlage III
| legal_status = Resep saja, WHO Recommended Schedule III
| dependency_liability = High<ref name=Ait2018/>
| routes_of_administration = [[Administrasi oral|melalui mulut]]
| protein_bound = 80%
| bioavailability = 80–90%
| metabolism = [[Liver|Hati]], melalui [[sitokrom P450 3A4]]
| metabolites = alpha-hydroxyalprazolam, 4-hydroxyalprazolam, beta-hydroxyalprazolam
| onset = less than an hour<ref name=Lill2016>{{cite book |last1=Lilley |first1=Linda Lane |last2=Snyder |first2=Julie S. |last3=Collins |first3=Shelly Rainforth |title=Pharmacology for Canadian Health Care Practice |date=2016 |publisher=Elsevier Health Sciences |isbn=9781771720663 |page=329 |url=https://books.google.ca/books?id=dNgoDwAAQBAJ&pg=PA329 }}</ref>
| duration_of_action = 6 jam<ref name=Lill2016/>
| elimination_half-life = Pelepasan cepat: 11–13 hours<ref name=AHFS2018/><br />Pelepasan diperpanjang: 11–16 hours<ref name=AHFS2018/>
| excretion = [[Kidney]]
<!--Identifiers-->| IUPHAR_ligand = 7111
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 28981-97-7
| ATC_prefix = N05
| ATC_suffix = BA12
| PubChem = 2118
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00404
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2034
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = YU55MQ3IZY
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00225
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 2611
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 661
<!--Chemical data-->| C = 17
| H = 13
| Cl = 1
| N = 4
| smiles = ClC1=CC2=C(C=C1)N3C(C)=NN=C3CN=C2C4=CC=CC=C4
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = VREFGVBLTWBCJP-UHFFFAOYSA-N
| drug_name =
| alt =
| caption =
| type =
| licence_EU =
| pregnancy_AU =
| pregnancy_category =
| licence_US =
}}
'''Alprazolam''' merupakan obat golongan [[Benzodiazepin]] dengan nama kimia 8-Kloro-1-metil-6-fenil-4H-s-triazolo[4,3- a][1,4] benzodiazepine, diklasifikasikan sebagai [[Psikotropika|Psikotropika golongan IV]].<ref>{{Cite web|url=https://elibrary.dprd.jatengprov.go.id/peraturan-menteri-kesehatan-republik-indonesia-nomor-3-tahun-2017-tentang-perubahan-penggolongan-psikotropika|title=PERATURAN MENTERI KESEHATAN REPUBLIK INDONESIA NOMOR 3 TAHUN 2017 TENTANG PERUBAHAN PENGGOLONGAN PSIKOTROPIKA {{!}} e-Library DPRD Jawa Tengah|website=elibrary.dprd.jatengprov.go.id|access-date=2019-11-13}}</ref> Alprazolam sering digunakan sebagai terapi pada gangguan cemas, serangan panik, dan kecemasan yang disebabkan oleh depresi. Obat ini bekerja pada kompleks reseptor GABA<sub>A</sub>-Benzodiazepin yang terdapat di sistem saraf pusat, sehingga menimbulkan efek inhibisi atau efek menenangkan.
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