[[Rajshree Thakur]] dan [[Manav Gohil]] berperan sebagai pemeran utama.<ref>{{Cite web|last=|first=|date=|title=Rajshree Thakur on Shaadi Mubarak: Have to draw a thin line between not being a bechari or arrogant|url=https://m.timesofindia.com/videos/tv/hindi/rajashree-thakur-talks-about-her-comeback-show-shaadi-mubarak/videoshow/77767414.cms|url-status=live|archive-url=|archive-date=|access-date=|website=The Times of India}}</ref><ref>{{Cite web|last=|first=|date=|title=Manav Gohil Talks About His New Show, Shaadi Mubarak, And Shooting In The New Normal|url=https://www.mid-day.com/articles/manav-gohil-talks-about-his-new-show-shaadi-mubarak-and-shooting-in-the-new-normal/22967302|url-status=live|archive-url=|archive-date=|access-date=|website=[[Mid Day]]}}</ref> BesidesSelain, Sandeep Mehta, [[Anjalie Gupta (disambiguation)|Anjali Gupta]], [[Rajeshwari Sachdev]], [[Manu Malik]], Akansha Sareen, [[Dolly Minhas]], [[Sailesh Gulabani]] dan [[Nisha Rawal]] juga ikut serta dalam pemeran serial ini.<ref>{{Cite web|last=|first=|date=|title=Rajeshwari Sachdev joins the cast of Shashi-Sumeet Mittal's next show|url=https://timesofindia.indiatimes.com/tv/news/hindi/rajeshwari-sachdev-joins-the-cast-of-shashi-sumeet-mittals-next-show/articleshow/76947284.cms|url-status=live|archive-url=|archive-date=|access-date=|website=The Times of India}}</ref><ref>{{Cite web|last=|first=|date=|title=Rajashree Thakur to make a comeback after 5 years in Shaadi Mubarak|url=https://www.indiatoday.in/television/soaps/story/rajashree-thakur-to-make-a-comeback-after-5-years-in-shaadi-mubarak-1705751-2020-07-29|url-status=live|archive-url=|archive-date=|access-date=|website=India Today}}</ref><ref>{{Cite web|last=|first=|date=|title=Rajshree Thakur seeks inspiration from veteran actress Neena Gupta for her upcoming role as Preeti Jindal in 'Shaadi Mubarak'|url=https://m.timesofindia.com/tv/news/hindi/rajshree-thakur-seeks-inspiration-from-veteran-actress-neena-gupta-for-her-upcoming-role-as-preeti-jindal-in-shaadi-mubarak/articleshow/77727202.cms|url-status=live|archive-url=|archive-date=|access-date=|website=The Times of India}}</ref><ref>{{Cite web|last=|first=|date=|title='Choti Sarrdaarni' actress Dolly Minhas to play Manav Gohil's mother in 'Shaadi Mubarak'|url=https://m.timesofindia.com/tv/news/hindi/choti-sarrdaarni-actress-dolly-minhas-to-play-manav-gohils-mother-in-shaadi-mubarak/articleshow/77074300.cms|url-status=live|archive-url=|archive-date=|access-date=|website=The Times of India}}</ref><ref>{{Cite web|last=|first=|date=|title=Nisha Rawal to become part of serial 'Shaadi Mubarak Ho'|url=https://news.abplive.com/videos/entertainment/television-nisha-rawal-to-become-part-of-serial-shaadi-mubarak-ho-1314138|url-status=live|archive-url=|archive-date=|access-date=|website=ABP News}}</ref> Awalnya Kabeer Kumar berperan untuk memerankan karakter putra Preeti, Tarun, tetapi digantikan sebelum penembakan dilanjutkan pada Juli 2020 oleh Gaurav Sharma karena pandemi COVID-19 dan kemudian ia diberi karakter sepupu Keertan..<ref>{{Cite web|last=|first=|date=|title=Kabeer Kumar opts out of Shashi-Sumeet Mittal's show, Gaurav Sharma steps in|url=https://timesofindia.indiatimes.com/tv/news/hindi/kabeer-kumar-opts-out-of-shashi-sumeet-mittals-show-gaurav-sharma-steps-in/articleshow/76983722.cms|url-status=live|archive-url=|archive-date=|access-date=|website=The Times of India}}</ref>
Pada pertengahan Oktober 2020, aktris utama [[Rajshree Thakur]] memerankan Preeti berhenti untuk menjaga kesehatan mereka dengan menyatakan jadwal padat dari serial tersebut dan segera digantikan oleh [[Rati Pandey]].<ref>{{Cite web|last=|first=|date=|title=Rajshree Thakur quits Shaadi Mubarak citing hectic schedule|url=https://indianexpress.com/article/entertainment/television/rajshree-thakur-quits-shaadi-mubarak-citing-hectic-schedule-6724788/|url-status=live|archive-url=|archive-date=|access-date=|website=The Indian Express}}</ref> Segera kemudian, [[Barkha Sengupta]] berperan sebagai mantan istri Keertan.<ref>{{Cite web|last=|first=|date=|title=Telly Tattle: Barkha Bisht Sengupta To Enter Shaadi Mubarak|url=https://www.mid-day.com/articles/telly-tattle-barkha-bisht-sengupta-to-enter-shaadi-mubarak/23063201|url-status=live|archive-url=|archive-date=|access-date=|website=Mid Day}}</ref>
