Argumen penutup kampanye Warnock berfokus pada pembayaran stimulus $ 2.000 yang dia dan [[Jon Ossoff]] akan setujui jika mereka memenangkan pemilihan dan menjadikan Demokrat sebagai mayoritas di Senat.<ref>{{Cite web|title=In Georgia, Democrats close with populist pitch vowing $2,000 stimulus checks|url=https://www.nbcnews.com/politics/congress/georgia-democrats-close-populist-pitch-vowing-2-000-stimulus-checks-n1252805|access-date=2021-01-05|website=NBC News|language=en|archive-date=6 Januari 2021|archive-url=https://web.archive.org/web/20210106141559/https://www.nbcnews.com/politics/congress/georgia-democrats-close-populist-pitch-vowing-2-000-stimulus-checks-n1252805|url-status=live}}</ref>
Dalam pemilihan putaran kedua tanggal 5 Januari 2021, Warnock mengalahkan Loeffler dengan perolehan 51% suara. Dengan kemenangan ini, ia mengukir sejarah dengan menjadi senator kulit hitam pertama dari Georgia.<ref name=chicagotribune.com>{{cite web| url =https://www.chicagotribune.com/election-2020/ct-nw-georgia-runoff-election-results-20210105-torujxxjizdzphqhempcuohwl4-htmlstory.html| title =Georgia election updates: Raphael Warnock makes history with win as Democrats near control of Senate; 2nd runoff race too early to call| last1 =Peoples| first1 =Steve | last2 =Barrow | first2 =Bill | last3 =Bynum | first3 =Russ | date = 6 Januari 2021 | website =Chicago Tribune | access-date = 9 Januari 2021}}</ref> Hasil pemilunya disertifikasi pada 19 Januari.<ref>{{Cite news|last=Gardner|first=Amy|last2=Werner|first2=Erica|date=19 Januari 2021|title=Georgia certifies Ossoff and Warnock victories, paving way for Democratic control of Senate|language=en-US|work=Washington Post|url=https://www.washingtonpost.com/politics/georgia-certifies-ossoff-warnock-victories-paving-way-for-democratic-control-of-senate/2021/01/19/8b9cf672-5a59-11eb-a976-bad6431e03e2_story.html|access-date=19 Januari 2021|issn=0190-8286}}</ref>
Pada 6 Januari 2021, beberapa jaringan media massa mengumumkan Warnock memenangi pemilihan.<ref name="cnn-results">{{cite web|url=https://www.cnn.com/election/2020/results/state/georgia/senate-special-election-runoff|title=Senate Special Runoff: Georgia|access-date=January 6, 2020|website=[[CNN]]|archive-date=January 6, 2021|archive-url=https://web.archive.org/web/20210106141443/https://www.cnn.com/election/2020/results/state/georgia/senate-special-election-runoff|url-status=live}} (accessed 2:05 am EST)</ref><ref name="nbc-win">{{cite tweet|number=1346710425505771520|title=BREAKING: Raphael Warnock wins U.S. Senate runoff in Georgia, NBC News projects. https://nbcnews.to/3hKCaFU|author=NBC News|author-link=NBC News|user=NBCNews|date=January 6, 2020}} (1:49 am EST)</ref><ref name="cbs-win">{{cite tweet|number=1346712212983996422|title=BREAKING: CBS News projects Raphael Warnock defeats Kelly Loeffler in the Georgia Senate runoff. This is a Democratic pickup.|author=CBS News|author-link=CBS News|user=CBSNews|date=January 6, 2020}} (1:56 am EST)</ref><ref name="abc-win">{{cite web|url=https://abcnews.go.com/Politics/live-updates/Georgia-runoffs-election-results/?id=75049098#75075079|title=ABC News projects Warnock defeats Loeffler|date=January 6, 2020|first=Kendall|last=Karson|website=[[ABC News]]|access-date=January 6, 2021|archive-date=January 6, 2021|archive-url=https://web.archive.org/web/20210106141529/https://abcnews.go.com/Politics/live-updates/Georgia-runoffs-election-results/?id=75049098#75075079|url-status=live}} (2:00 am EST)</ref><ref name="ap-call">{{cite web|url=https://apnews.com/article/85d4caf2e38b5cc3cc21bdd4a6691d6d|title=Warnock makes history with Senate win as Dems near majority|3=|first1=Bill|last1=Barrow|first2=Russ|last2=Bynum|first3=Steve|last3=Peoples|date=January 6, 2020|website=[[Associated Press]]|access-date=January 6, 2021|archive-date=January 6, 2021|archive-url=https://web.archive.org/web/20210106141540/https://apnews.com/article/85d4caf2e38b5cc3cc21bdd4a6691d6d|url-status=live}}</ref> Dengan begitu, Warnock akan menjadi anggota Partai Demokrat Afrika-Amerika pertama dalam sejarah yang mewakili bekas [[Konfederasi Amerika|negara bagian Konfederasi]] di Senat Amerika Serikat.<ref>{{cite web |title=African American Senators |url=https://www.senate.gov/pagelayout/history/h_multi_sections_and_teasers/Photo_Exhibit_African_American_Senators.htm |website=United States Senate |publisher=United States Government |access-date=6 January 2021 |archive-date=July 2, 2018 |archive-url=https://web.archive.org/web/20180702035451/https://www.senate.gov/pagelayout/history/h_multi_sections_and_teasers/Photo_Exhibit_African_American_Senators.htm |url-status=live }}</ref><ref>{{Cite web|last=Thebault|first=Reis|last2=Scherer|first2=Michael|last3=Wootson|first3=Cleve R., Jr.|date=2021-01-05|title=Raphael Warnock wins Georgia runoff election against Sen. Loeffler, lifting Democratic hopes of claiming Senate majority|url=https://www.washingtonpost.com/politics/perdue-ossoff-loeffler-warnock-georgia-senate/2021/01/05/7d7b5afe-4f5d-11eb-83e3-322644d82356_story.html|url-status=live|archive-url=https://web.archive.org/web/20210106141547/https://www.washingtonpost.com/politics/perdue-ossoff-loeffler-warnock-georgia-senate/2021/01/05/7d7b5afe-4f5d-11eb-83e3-322644d82356_story.html|archive-date=January 6, 2021|access-date=2021-01-06|website=[[Washington Post]]}}: "Warnock will be the first African American Democratic senator from a former Confederate state" <!-- Quote added because was disputed multiple times by extended editors. --></ref><ref>{{cite news |last1=Martin |last2=Fausset |first1=Jonathan |first2=Richard |date=January 6, 2021 |title=Warnock Beats Loeffler in Georgia Senate Race |url=https://www.nytimes.com/2021/01/06/us/politics/warnock-loeffler-ossoff-perdue-georgia-senate.html |work=The New York Times |location=New York, NY |access-date=January 6, 2021}}</ref>
Pada 20 Januari 2021, Warnock dilantik menjadi [[Senator Amerika Serikat]] di [[Kongres Amerika Serikat ke-117|Kongres ke-117]] oleh [[Wakil Presiden Amerika Serikat|Wakil Presiden]] [[Kamala Harris]].
