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[[File:Endocarditis ultrasound.JPG|thumb|[[Ekokardiografi|Ekokardiogram]] yang menunjukkan endokarditis infektif pada [[katup trikuspid]] (panah putih). Pasien mendapat terapi konvensional yang terdiri dari [[ampisilin]], [[imipenem]], dan [[glukokortikoid]]. Pasien pulih sepenuhnya setelah dilakukan operasi jantung.<ref>{{cite journal | vauthors = Koya D, Shibuya K, Kikkawa R, Haneda M | title = Successful recovery of infective endocarditis-induced rapidly progressive glomerulonephritis by steroid therapy combined with antibiotics: a case report | journal = BMC Nephrology | volume = 5 | issue = 1 | pages = 18 | date = Desember 2004 | pmid = 15610562 | pmc = 544880 | doi = 10.1186/1471-2369-5-18 }}</ref>|alt=Ekokardiogram potongan melintang dari jantung manusia. Pada gambar kedua, panah putih menunjukkan adanya infeksi di katup trikuspid.]]
Pada umumnya, infeksi pada organ dalam seperti osteomielitis atau [[endokarditis infektif]] sebaiknya diobati dengan antibiotik bakterisida, bukan antibiotik bakteriostatik. Walau demikian, tetap dilakukan studi praklinis untuk menilai efikasi linezolid untuk infeksi tersebut<ref name=Barbachyn/> dan telah digunakan untuk mengobati jenis infeksi tersebut dalam praktik klinis.<ref name="Barbachyn" /> Linezolid menjadi pilihan terapi untuk endokarditis infektif yang disebabkan bakteri Gram-positif multi-resisten walau tidak terdapat bukti yang kuat untuk mendukung penggunaannya.<ref>{{cite journal |vauthors=Pankey GA, Sabath LD |title=Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections |journal=[[Clinical Infectious Diseases]] |volume=38 |issue=6 |pages=864–70 |date=Maret 2004 |pmid=14999632 |doi=10.1086/381972 |issn=1058-4838|doi-access=free }}</ref><ref name=Falagas>{{cite journal |vauthors=Falagas ME, Manta KG, Ntziora F, Vardakas KZ |title=Linezolid for the treatment of patients with endocarditis: a systematic review of the published evidence |journal=Journal of Antimicrobial Chemotherapy |volume=58 |issue=2 |pages=273–80 |date=Agustus 2006 |pmid=16735427 |doi=10.1093/jac/dkl219 |doi-access=free }}</ref> Hasil penggunaan linezolid dalam terapi endokarditis yang disebabkan enterokokus bervariasi, dengan sebagian kasus berhasil terobati dan sebagian lainnya gagal.<ref>{{cite journal |vauthors=Babcock HM, Ritchie DJ, Christiansen E, Starlin R, Little R, Stanley S |title=Successful treatment of vancomycin-resistant ''Enterococcus'' endocarditis with oral linezolid |journal=Clinical Infectious Diseases |volume=32 |issue=9 |pages=1373–5 |date=Mei 2001 |pmid=11303275 |doi=10.1086/319986 |issn=1058-4838|doi-access=free }}</ref><ref>{{cite journal |vauthors=Ang JY, Lua JL, Turner DR, Asmar BI |title=Vancomycin-resistant ''Enterococcus faecium'' endocarditis in a premature infant successfully treated with linezolid |journal=The Pediatric Infectious Disease Journal |volume=22 |issue=12 |pages=1101–3 |date=Desember 2003 |pmid=14688576 |doi=10.1097/01.inf.0000101784.83146.0c |issn=0891-3668}}</ref><ref>{{cite journal |vauthors=Archuleta S, Murphy B, Keller MJ |title=Successful treatment of vancomycin-resistant ''Enterococcus faecium'' endocarditis with linezolid in a renal transplant recipient with human immunodeficiency virus infection |journal=Transplant Infectious Disease |volume=6 |issue=3 |pages=117–9 |date=September 2004 |pmid=15569227 |doi=10.1111/j.1399-3062.2004.00059.x |issn=1398-2273}}</ref><ref>{{cite journal |vauthors=Zimmer SM, Caliendo AM, Thigpen MC, Somani J |title=Failure of linezolid treatment for enterococcal endocarditis |journal=Clinical Infectious Diseases |volume=37 |issue=3 |pages=e29–30 |date=Agustus 2003 |pmid=12884185 |doi=10.1086/375877 |issn=1058-4838}}</ref><ref>{{cite journal |vauthors=Tsigrelis C, Singh KV, Coutinho TD, Murray BE, Baddour LM |title=Vancomycin-Resistant Enterococcus faecalis Endocarditis: Linezolid Failure and Strain Characterization of Virulence Factors |journal=[[Journal of Clinical Microbiology]] |volume=45 |issue=2 |pages=631–5 |date=Februari 2007 |pmid=17182759 |pmc=1829077 |doi=10.1128/JCM.02188-06 }}</ref><ref>{{cite journal |vauthors=Berdal JE, Eskesen A |title=Short-term success, but long-term treatment failure with linezolid for enterococcal endocarditis |journal=Scandinavian Journal of Infectious Diseases |volume=40 |issue=9 |pages=765–6 |year=2008 |pmid=18609208 |doi=10.1080/00365540802087209 |issn=0036-5548}}</ref> [[Pengobatan bertumpu bukti|Dari bukti lemah hingga sedang]] juga mendukung penggunaan linezolid pada infeksi tulang dan sendi seperti osteomielitis kronis. Hanya saja, efek samping dari linezolid perlu diperhatikan untuk penggunaan jangka panjang.<ref>{{cite journal |vauthors=Falagas ME, Siempos II, Papagelopoulos PJ, Vardakas KZ |title=Linezolid for the treatment of adults with bone and joint infections |journal=International Journal of Antimicrobial Agents |volume=29 |issue=3 |pages=233–9 |date=Maret 2007 |pmid=17204407 |doi=10.1016/j.ijantimicag.2006.08.030 |issn=0924-8579}} Review.</ref><ref>{{cite journal |vauthors=Bassetti M, Vitale F, Melica G, etal |title=Linezolid in the treatment of Gram-positive prosthetic joint infections |journal=Journal of Antimicrobial Chemotherapy |volume=55 |issue=3 |pages=387–90 |date=Maret 2005 |pmid=15705640 |doi=10.1093/jac/dki016 |doi-access=free }}</ref><ref>{{cite journal |vauthors=Aneziokoro CO, Cannon JP, Pachucki CT, Lentino JR |title=The effectiveness and safety of oral linezolid for the primary and secondary treatment of osteomyelitis |journal=Journal of Chemotherapy |volume=17 |issue=6 |pages=643–50 |date=Desember 2005 |pmid=16433195 |issn=1120-009X |doi=10.1179/joc.2005.17.6.643}}</ref><ref>{{cite journal |vauthors=Senneville E, Legout L, Valette M, etal |title=Effectiveness and tolerability of prolonged linezolid treatment for chronic osteomyelitis: a retrospective study |journal=Clinical Therapeutics |volume=28 |issue=8 |pages=1155–63 |date=Agustus 2006 |pmid=16982292 |doi=10.1016/j.clinthera.2006.08.001 |issn=0149-2918}}</ref><ref>{{cite journal |vauthors=Rao N, Hamilton CW |title=Efficacy and safety of linezolid for Gram-positive orthopedic infections: a prospective case series |journal=Diagnostic Microbiology and Infectious Disease |volume=59 |issue=2 |pages=173–9 |date=Oktober 2007 |pmid=17574788 |doi=10.1016/j.diagmicrobio.2007.04.006 |issn=0732-8893}}</ref><ref>{{cite journal |vauthors=Papadopoulos A, Plachouras D, Giannitsioti E, Poulakou G, Giamarellou H, Kanellakopoulou K |title=Efficacy and tolerability of linezolid in chronic osteomyelitis and prosthetic joint infections: a case-control study |journal=Journal of Chemotherapy |volume=21 |issue=2 |pages=165–9 |date=April 2009 |pmid=19423469 |issn=1120-009X |doi=10.1179/joc.2009.21.2.165}}</ref>
==Interaksi==
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