Velázquez lahir di [[Chicago]], [[Illinois]]. Ia [[Puerto Rico Amerika|berdarah Puerto Rico]]. Setelah lulus dari [[Notre Dame High School for Girls]],<ref>[{{Cite web |url=http://www.cookcountyclerk.com/sweethomecookcounty/pages/nadinevelazquez.aspx |title=Nadine Velázquez, Actress (profile) – Cook County (IL) Clerk's Office.]{{webarchive|access-date=2019-02-14 |archive-date=2012-02-10 |archive-url=https://web.archive.org/web/20120210200705/http://cookcountyclerk.com/sweethomecookcounty/Pages/NadineVelázquezNadineVel%C3%A1zquez.aspx |datedead-url=February 10, 2012no }}</ref> ia meraih gelar sarjana dalam bidang pemasaran dari [[Columbia College Chicago]] pada 2001.<ref>[https://www.usnews.com/education/blogs/college-flashback/2008/09/26/nadine-velazquez Vaccino, Steven. "Celebrity College Flashback: Nadine Velázquez," ''U.S. News & World Report'', September 26, 2008.]</ref>
