Aisyah wafat di rumahnya di Madinah pada tanggal 17 Ramadhan 58 H (16 Juli 678 M), pada saat itu ia berusia 67 tahun.<ref name="Siddiqui">{{factharvnb|Al-Nasa'i|1997|p=108}}{{quote|‘A’isha was eighteen years of age at the time when the Holy Prophet (peace and blessings of Allah be upon him) died and she remained a widow for forty-eight years till she died at the age of sixty-seven. She saw the rules of four caliphs in her lifetime. She died in Ramadan 58 AH during the caliphate of Mu‘awiya...}}</ref> Sahabat Nabi, [[Abu Hurairah]] memimpin penguburannya setelah salat tahajud dan ia dikuburkan di [[Jannatul Baqi|Jannat al-Baqi']].{{sfn|Ibnu Katsir|p=97}}{{Istri-istriMuhammad}}