Sindrom serotonin: Perbedaan antara revisi

Studi epidemiologis sindrom serotonin sulit dilakukan karena banyak dokter tidak menyadari diagnosisnya atau mereka mungkin melewatkan sindrom tersebut karena manifestasinya yang bervariasi.<ref name = Boyer>{{Cite journal|last=Wang|first=Robert Z.|last2=Vashistha|first2=Vishal|last3=Kaur|first3=Sukhdeep|last4=Houchens|first4=Nathan W.|date=2016-11|title=Serotonin syndrome: Preventing, recognizing, and treating it|url=https://www.ccjm.org//lookup/doi/10.3949/ccjm.83a.15129|journal=Cleveland Clinic Journal of Medicine|language=en|volume=83|issue=11|pages=810–816|doi=10.3949/ccjm.83a.15129|issn=0891-1150}}</ref><ref>{{Cite journal|last=Sampson|first=E.|last2=Warner|first2=J. P.|date=1999-11|title=Serotonin syndrome: potentially fatal but difficult to recognize|url=https://pubmed.ncbi.nlm.nih.gov/10818648|journal=The British Journal of General Practice: The Journal of the Royal College of General Practitioners|volume=49|issue=448|pages=867–868|issn=0960-1643|pmc=1313553|pmid=10818648}}</ref> Pada 1998, sebuah survei yang dilakukan di Inggris menemukan bahwa 85% dari [[dokter umum]] yang meresepkan antidepresan nefazodon tidak menyadari sindrom serotonin.<ref name = Mackay>{{Cite journal|last=Mackay|first=F. J.|last2=Dunn|first2=N. R.|last3=Mann|first3=R. D.|date=1999-11|title=Antidepressants and the serotonin syndrome in general practice|url=https://pubmed.ncbi.nlm.nih.gov/10818650|journal=The British Journal of General Practice: The Journal of the Royal College of General Practitioners|volume=49|issue=448|pages=871–874|issn=0960-1643|pmc=1313555|pmid=10818650}}</ref> Insiden sindrom serotonin meningkat dikarenakan ada banyak obat pro-serotonergik (obat yang meningkatkan kadar serotonin) yang saat ini digunakan dalam praktik klinis.<ref name = Graudins>{{Cite journal|last=Graudins|first=A.|last2=Stearman|first2=A.|last3=Chan|first3=B.|date=1998-07|title=Treatment of the serotonin syndrome with cyproheptadine|url=https://pubmed.ncbi.nlm.nih.gov/9696181|journal=The Journal of Emergency Medicine|volume=16|issue=4|pages=615–619|doi=10.1016/s0736-4679(98)00057-2|issn=0736-4679|pmid=9696181}}</ref> Satu penelitian surveilans pascapemasaran mengidentifikasi insiden 0,4 kasus per 1000 pasien-bulan untuk pasien yang memakai nefazodon.<ref name = Mackay/> Selain itu, sekitar 14 hingga 16 persen orang yang overdosis SSRI diperkirakan mengembangkan sindrom serotonin.<ref name = Isbister>{{Cite journal|last=IsbisterHawton|first=Geoffrey K.Keith|last2=BoweBergen|first2=Steven J.Helen|last3=DawsonSimkin|first3=AndrewSue|last4=WhyteCooper|first4=Ian M.Jayne|last5=Waters|first5=Keith|last6=Gunnell|first6=David|last7=Kapur|first7=Navneet|date=20042010-05|title=RelativeToxicity toxicityof antidepressants: rates of selectivesuicide serotoninrelative reuptaketo inhibitorsprescribing (SSRIs)and innon-fatal overdose|url=https://pubmedwww.ncbicambridge.nlm.nih.govorg/15362595core/product/identifier/S000712500025246X/type/journal_article|journal=British Journal of Toxicology. Clinical ToxicologyPsychiatry|language=en|volume=42196|issue=35|pages=277–285354–358|doi=10.10811192/clt-120037428bjp.bp.109.070219|issn=07310007-38101250|pmc=PMC2862059|pmid=1536259520435959}}</ref>