Linezolid: Perbedaan antara revisi
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Sebagai inhibitor sintesis protein, linezolid bekerja dengan menghambat [[Translasi (genetik)|proses translasi pada bakteri]].<ref name=Swaney1998/> Hal tersebut menjadikan obat ini dapat [[bakteriostatik|menghentikan pertumbuhan]] atau [[bakterisida|membunuh bakteri]].<ref name=AHFS2016/> Walau banyak antibiotik lain yang bekerja dengan cara serupa, mekanisme aksi pasti dari linezolid tampak berbeda karena dia menghambat proses inisiasi sintesis protein daripada menghambat di tahapan-tahapan berikutnya.<ref name=Swaney1998>{{cite journal | vauthors = Swaney SM, Aoki H, Ganoza MC, Shinabarger DL | title = The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria | journal = Antimicrobial Agents and Chemotherapy | volume = 42 | issue = 12 | pages = 3251–5 | date = Desember 1998 | pmid = 9835522 | pmc = 106030 | url = http://aac.asm.org/cgi/reprint/42/12/3251.pdf | doi = 10.1128/AAC.42.12.3251 }}</ref> Hingga 2014, [[resistensi antibiotik|resistensi]] terhadap linezolid masih rendah.<ref>{{cite journal | vauthors = Mendes RE, Deshpande LM, Jones RN | title = Linezolid update: stable in vitro activity following more than a decade of clinical use and summary of associated resistance mechanisms | journal = Drug Resistance Updates | volume = 17 | issue = 1–2 | pages = 1–12 | date = April 2014 | pmid = 24880801 | doi = 10.1016/j.drup.2014.04.002 | quote = Emergence of resistance has been limited ... It is still uncertain whether the occurrences of such isolates are becoming more prevalent. }}</ref> Linezolid termasuk dalam antibiotik kelas [[2-Oksazolidon|oksazolidinon]].<ref name=AHFS2016/>
Linezolid ditemukan pada pertengahan 1990-an. Obat ini mendapat persetujuan untuk dipasarkan pada tahun 2000.<ref>{{cite book| vauthors = Li JJ, Corey EJ |title=Drug Discovery: Practices, Processes, and Perspectives|date=2013|publisher=John Wiley & Sons|isbn=978-1-118-35446-9|page=6|url=https://books.google.com/books?id=mIyxO5cLEAcC&pg=PA6|language=en|url-status=live|archive-url=https://web.archive.org/web/20170910172617/https://books.google.com/books?id=mIyxO5cLEAcC&pg=PA6|archive-date=10 September 2017}}</ref><ref>{{cite book|last1=Torok|first1=Estee|last2=Moran|first2=Ed|last3=Cooke|first3=Fiona | name-list-format = vanc |title=Oxford Handbook of Infectious Diseases and Microbiology|date=2009|publisher=OUP Oxford|isbn=978-0-19-103962-1|chapter-url=https://books.google.com/books?id=5W-WBQAAQBAJ&pg=PT56|language=en|chapter=Chapter 2 Antimicrobials|url-status=live|archive-url=https://web.archive.org/web/20170908143257/https://books.google.com/books?id=5W-WBQAAQBAJ&pg=PT56|archive-date=8 September 2017}}</ref> Obat ini masuk dalam [[Daftar Obat Esensial Organisasi Kesehatan Dunia]].<ref name="WHO21st">{{cite book|vauthors=((World Health Organization))|year=2021|url=https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02|title=World Health Organization model list of essential medicines: 22st list 2021|location=Geneva|publisher=World Health Organization|id=WHO/MHP/HPS/EML/2021.02. License: CC BY-NC-SA 3.0 IGO|author-link=World Health Organization|url-status=live
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