EA awalnya mengirimkan 3,5 juta unit Mass Effect 3 di bulan pertama.<ref>{{Cite journal|last=Skadsem|first=Hans Joakim|last2=Gardner|first2=Dave|last3=Beltrán-Jiménez|first3=Katherine|last4=Kragset|first4=Steinar|last5=Delabroy|first5=Laurent|last6=Ruckert|first6=Frank|date=2020-02-25|title=Fluid Migration Characterization of Cemented Sections Retrieved from a North Sea Production Well|url=http://dx.doi.org/10.2118/199662-ms|journal=Day 1 Tue, March 03, 2020|publisher=SPE|doi=10.2118/199662-ms}}</ref> Itu terjual 349.000 salinan digital di PC saja pada akhir Maret 2012.<ref>{{Cite web|date=2017-10-11|title=Worldwide semiconductor market by region|url=http://dx.doi.org/10.1787/9789264276284-graph28-en|website=dx.doi.org|access-date=2022-07-23}}</ref> Permainan terjual lebih dari 890.000 eksemplar dalam 24 jam pertama. Menurut The NPD Group, album ini terjual 1,3 juta kopi fisik di bulan debutnya,<ref>{{Cite book|date=2012-12-31|url=http://dx.doi.org/10.18356/7b2df4b2-en|title=Original treaties and international agreements registered during the month of April 2012: Nos. 49477 to 49541|publisher=UN|isbn=978-92-1-055492-3|pages=7–13}}</ref> yang berjumlah dua kali lipat dari total Mass Effect 2 selama bulan pembukaannya di Januari 2010.<ref>{{Cite web|title=US Army Chemical Corps, Report, Report of Temporary Duty in Europe, 26 February - 31 March 1950, April 13, 1|url=http://dx.doi.org/10.1163/9789004346673.wmdo-01_288|website=Weapons of Mass Destruction|access-date=2022-07-23}}</ref> Pada Mei 2012, EA melaporkan bahwa Mass Effect 3 meraup lebih dari $200 juta selama Q4 FY12.<ref>{{Cite journal|last=Schappell|first=Bruce G|date=2012-12-11|title=FY12 Accomplishments|url=http://dx.doi.org/10.2172/1057599}}</ref>
