Spironolakton: Perbedaan antara revisi

| metabolism = [[Liver]], lainnya:<br />• [[Deacetylation]] via {{abbrlink|CES|carboxylesterase}}<br />• ''S''-[[Oxidation|Oxygenation]] via {{abbrlink|FOM|flavin-containing monooxygenase}}<br />• ''S''-[[Methylation]] via {{abbrlink|TMT|thiol S-methyltransferase}}<br />• [[Dethioacetylation]]<br />• [[Hydroxylation]] via [[CYP3A4]]<br />• [[Lactone]] [[hydrolysis]] via [[PON3]])<ref name="Sica2005" /><ref name="pmid18729003" /><ref name="Parkinson2001">{{cite book|author=Andrew Parkinson|title=Biotransformation of Xenobiotics|url=https://books.google.com/books?id=pAovcgAACAAJ|year=2001|publisher=McGraw-Hill|pages=137–138, 169, 171, 180, 195, 208}}</ref><ref name="Klaassen2007">{{cite book|author=Curtis D. Klaassen|title=Casarett & Doull's Toxicology: The Basic Science of Poisons, Seventh Edition|url=https://books.google.com/books?id=4yi7-j48uhIC|date=11 December 2007|publisher=McGraw Hill Professional|isbn=978-0-07-159351-9|page=173|quote=Some P450 enzymes (such as the rate enzyme CYP2A1) preferentially catalyze the 6α-hydroxylation reaction, whereas other P450 enzymes (such as the CYP3A enzymes in all mammalian species) preferentially catalyze the 6β-hydroxylation reaction (which is a major route of hepatic steroid biotransformation).}}</ref><ref name="pmid7895608">{{cite journal | vauthors = Los LE, Pitzenberger SM, Ramjit HG, Coddington AB, Colby HD | title = Hepatic metabolism of spironolactone. Production of 3-hydroxy-thiomethyl metabolites | journal = Drug Metab. Dispos. | volume = 22 | issue = 6 | pages = 903–8 | date = 1994 | pmid = 7895608 | doi = | url = http://dmd.aspetjournals.org/content/22/6/903}}</ref><ref name="BlackElliott2006">{{cite book|author1=Henry R. Black|author2=William Elliott|title=Hypertension: A Companion to Braunwald's Heart Disease|url=https://books.google.com/books?id=42Fcmne6_w8C&pg=PA295|date=28 December 2006|publisher=Elsevier Health Sciences|isbn=978-1-4377-1078-6|pages=295–}}</ref> <ref name="pmid14579013">{{cite journal | vauthors = Draganov DI, La Du BN | title = Pharmacogenetics of paraoxonases: a brief review | journal = Naunyn Schmiedebergs Arch. Pharmacol. | volume = 369 | issue = 1 | pages = 78–88 | date = January 2004 | pmid = 14579013 | doi = 10.1007/s00210-003-0833-1 | url = | hdl = 2027.42/46312 }}</ref>