Semua pembalap dan tim yang berpartisipasi pada balapan ini merupakan pembalap dan tim yang sama dengan yang terdaftar pada daftar peserta musim ini.{{citation needed}} Terdapat empat pembalap yang direncanakan akan tampil pada sesi latihan pertama: [[Pietro Fittipaldi]] akan menggantikan [[MickKevin SchumacherMagnussen]] di [[Haas F1 Team|Haas]];<ref>{{citeCite web|date=11 Oktober 2022-10-26|title=HaasMexico toCity fieldGrand FittipaldiPrix: inPreview Mexico{{!}} andHaas AbuF1 Dhabi FP1 sessionsTeam|url=https://www.formula1haasf1team.com/ennews/latest/article.haas-to-field-fittipaldi-in-mexico-andcity-abugrand-dhabiprix-fp1preview-sessions.7rRBJS1D4aeHiVJNQwSRym.html0|website=Haas F1 Team|language=en|access-date=25 Oktober 2022-10-27}}</ref> [[Liam Lawson]] akan menggantikan [[Yuki Tsunoda]] di [[Scuderia AlphaTauri|AlphaTauri]];<ref>{{Cite web|date=26 Oktober 2022|title=Red Bull-backed Liam Lawson to make another FP1 appearance with AlphaTauri at Mexico City GP|url=https://www.formula1.com/en/latest/article.red-bull-backed-liam-lawson-to-make-another-fp1-appearance-with-alphatauri.4BGCGHvs8xH5yMtNgkIOWU.html|language=en|access-date=26 Oktober 2022}}</ref> [[Jack Doohan]] akan menggantikan [[Esteban Ocon]] di [[Alpine F1 Team|Alpine]];<ref>{{Cite web|date=26 Oktober 2022|title=F2 racer Jack Doohan to drive FP1 in Mexico City and Abu Dhabi for Alpine {{!}} Formula 1®|url=https://www.formula1.com/en/latest/article.f2-racer-jack-doohan-to-drive-fp1-in-mexico-city-and-abu-dhabi-for-alpine.5nh1bA7xJOEPOVXJ3hen5q.html|website=www.formula1.com|language=en|access-date=2022-10-26}}</ref> dan [[Logan Sargeant]] akan menggantikan [[Alex Albon]] di [[Williams Grand Prix Engineering|Williams]].<ref>{{cite web|url=https://www.formula1.com/en/latest/article.williams-to-run-sargeant-in-two-further-fp1-sessions-in-2022.4dbWeVETWpf1cEaNZm4CEx.html|title=Williams to run Sargeant in two further FP1 sessions in 2022|author=Lawrence Barretto|language=en|date=22 Oktober 2022|access-date=25 Oktober 2022}}</ref>
