Vitamin B12: Perbedaan antara revisi

Untuk keracunan sianida, sejumlah besar hidroksokobalamin dapat diberikan secara intravena dan kadang-kadang dalam kombinasi dengan natrium tiosulfat.<ref>{{Cite web|last=M.D|first=Eric Toner|title=01-02-2007: FDA Approves Hydroxycobalamin for Cyanide Poisoning|url=https://www.centerforhealthsecurity.org/cbn/2007/cbnreport_01022007.html|website=Clinicians' Biosecurity News {{!}} Johns Hopkins Center for Health Security|language=en|access-date=2022-03-07|archive-date=2022-03-07|archive-url=https://web.archive.org/web/20220307011623/https://www.centerforhealthsecurity.org/cbn/2007/cbnreport_01022007.html|dead-url=yes}}</ref><ref>{{Cite journal|last=Meillier|first=Andrew|last2=Heller|first2=Cara|date=2015|title=Acute Cyanide Poisoning: Hydroxocobalamin and Sodium Thiosulfate Treatments with Two Outcomes following One Exposure Event|url=http://www.hindawi.com/journals/crim/2015/217951/|journal=Case Reports in Medicine|language=en|volume=2015|pages=1–4|doi=10.1155/2015/217951|issn=1687-9627|pmc=PMC4620268|pmid=26543483}}</ref> Mekanisme kerjanya: ligan hidroksikobalamin hidroksida digantikan oleh ion sianida toksik, dan sianokobalamin non-toksik yang dihasilkan diekskresikan dalam urin.<ref>{{Cite journal|last=Dart|first=Richard C.|date=2006|title=Hydroxocobalamin for acute cyanide poisoning: new data from preclinical and clinical studies; new results from the prehospital emergency setting|url=https://pubmed.ncbi.nlm.nih.gov/16990188|journal=Clinical Toxicology (Philadelphia, Pa.)|volume=44 Suppl 1|pages=1–3|doi=10.1080/15563650600811607|issn=1556-3650|pmid=16990188}}</ref>