Sebagai anggota dari One Direction, Payne mendukung Comic Relief,<ref>{{cite news|title=One Direction Raises Over £2 Million For Red Nose Day 2013|url=https://www.looktothestars.org/news/10927-one-direction-raises-over-2-million-for-red-nose-day-2013|publisher=Looktothestars.org|accessdate=20 October 2015}}</ref> dan sebuah gerakan bernama Action 1D "untuk mendapat masa depan yang lebih baik".<ref>{{cite news|last1=Sherman|first1=Maria|title=One Direction Launch Charity Initiative "Action 1D"|url=http://www.fuse.tv/videos/2015/07/one-direction-launch-charity-action-1d|publisher=Fuse.tv|accessdate=20 October 2015}}</ref>
Payne adalah pendukung aktif dari [[UNICEF]] dan bekerja sama dengan bintang tennis [[Andy Murray]], Jack Whitehall dan Clare Balding dalam mendukung Unicef UK’s Children in Danger Summer Disease Appeal.<ref>{{cite news|title=Andy Murray, Liam Payne, Jack Whitehall and Clare Balding film tennis comedy sketch for Unicef|url=http://blogs.unicef.org.uk/2015/06/16/andy-murray-liam-payne-one-drection-jack-whitehall-clare-balding-unicef-tennis-team-beat-disease/|publisher=Blogs.unicef.org.uk|accessdate=20 October 2015|deadurl=yes|archiveurl=https://web.archive.org/web/20151222103034/http://blogs.unicef.org.uk/2015/06/16/andy-murray-liam-payne-one-drection-jack-whitehall-clare-balding-unicef-tennis-team-beat-disease/|archivedate=22 December 2015}}</ref> Payne bekerja bersama bintangmantan pemilik tim balap sepeda[[Jordan Grand Prix]], motoryaitu [[Eddie Jordan]], dalam mendukung badan amal Inggris bernama CLIC Sargent.<ref>{{cite news|last1=Lee |first1=David |title=One Direction singer Liam Payne and sporting legends support CLIC Sargent event at Royal Windsor Racecourse |url=http://www.windsorexpress.co.uk/News/Areas/Windsor/Sporting-legends-and-One-Direction-singer-support-childrens-cancer-charity-event-at-Royal-Windsor-Racecourse-23062015.htm |work=Windsor Express |accessdate=20 October 2015 |deadurl=yes |archiveurl=https://web.archive.org/web/20151222102049/http://www.windsorexpress.co.uk/News/Areas/Windsor/Sporting-legends-and-One-Direction-singer-support-childrens-cancer-charity-event-at-Royal-Windsor-Racecourse-23062015.htm |archivedate=22 December 2015}}</ref> Payne adalah seorang duta untuk organisasi amal bernama Trekstock.<ref>{{cite news|title=1D stars Liam Payne and Harry Styles become cancer charity ambassadors|url=http://www.itv.com/news/central/update/2015-04-20/1d-stars-liam-payne-and-harry-styles-become-cancer-charity-ambassadors/|publisher=Itv.com|accessdate=20 October 2015}}</ref> Kampanye Payne bersama organisasi ini pada tahun 2013 menghasilkan $784,198.<ref>{{cite news|title=An Evening Out With Liam and Harry|url=https://www.prizeo.com/prizes/liam-and-harry/an-evening-out-with-liam-and-harry|publisher=Prizeo.com|accessdate=20 October 2015}}</ref> Dia menghasilkan $211,237 saat kampanyenya sendiri pada tahun 2015.<ref>{{cite news|title=The Charitable Nature of Liam Payne|url=http://trendom.co/the-charitable-nature-of-liam-payne/|publisher=Trendom.co|accessdate=20 October 2015|archive-url=https://web.archive.org/web/20151222083725/http://trendom.co/the-charitable-nature-of-liam-payne/|archive-date=22 December 2015|dead-url=yes}}</ref> Payne juga menjadi duta untuk Sustainable Development Goals yang juga dikenal sebagai kampanye Global Goals.<ref>{{cite web|url=http://www.globalgoals.org/ |title=The Global Goals |publisher=The Global Goals |date= |accessdate=20 October 2015}}</ref><ref>{{cite news|title=Global Goals Campaign Video|url=http://www.billboard.com/articles/news/6708119/one-direction-jennifer-lopez-global-goals-video|publisher=Billboard.com|accessdate=20 October 2015}}</ref> Payne juga memberikan bantuan untuk sebuah proyek anak muda sebanyak £6 juta bernama "The Youth Zone" di kampung halamannya di Wolverhampton.<ref>{{cite news|title=Newly-released footage of One Direction star Liam Payne at Wolverhampton Youth Zone event|url=https://www.expressandstar.com/news/2015/04/28/one-direction-star-liam-payne-in-wolverhampton-for-youth-zone-event/}}</ref>
