Glikasi: Perbedaan antara revisi

'''Glikasi''' (kadang disebut juga glikosilasi nonenzimatik) adalah ikatan kovalen antara gula dengan protein atau lemak.<ref name=":0">{{Citation|last1=Lima|first1=M.|title=Glycation|date=2013-01-01|url=http://www.sciencedirect.com/science/article/pii/B9780123786302001201|encyclopedia=Encyclopedia of Biological Chemistry (Second Edition)|pages=405–411|editor-last=Lennarz|editor-first=William J.|place=Waltham|publisher=Academic Press|language=en|doi=10.1016/b978-0-12-378630-2.00120-1|isbn=978-0-12-378631-9|access-date=2020-12-16|last2=Baynes|first2=J. W.|editor2-last=Lane|editor2-first=M. Daniel|archive-date=2021-01-04|archive-url=https://web.archive.org/web/20210104141551/https://www.sciencedirect.com/science/article/pii/B9780123786302001201|dead-url=no}}</ref> Jenis gula yang terlibat dalam proses glikasi adalah glukosa, fruktosa, dan derivatnya. Glikasi adalah proses yang tidak melibatkan enzim yang bertanggung jawab untuk terjadinya komplikasi mikro dan makrovaskuler pada penderita diabetes melitus dan terlibat dalam proses penuaan dan beberapa penyakit.<ref>{{Cite journal|last1=Glenn|first1=J.|last2=Stitt|first2=A.|year=2009|title=The role of advanced glycation end products in retinal ageing and disease|journal=Biochimica et Biophysica Acta (BBA) - General Subjects|volume=1790|issue=10|pages=1109–1116|doi=10.1016/j.bbagen.2009.04.016|pmid=19409449}}</ref><ref>{{Cite journal|last1=Semba|first1=R. D.|last2=Ferrucci|first2=L.|last3=Sun|first3=K.|last4=Beck|first4=J.|last5=Dalal|first5=M.|last6=Varadhan|first6=R.|last7=Walston|first7=J.|last8=Guralnik|first8=J. M.|last9=Fried|first9=L. P.|year=2009|title=Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women|journal=Aging Clinical and Experimental Research|volume=21|issue=2|pages=182–190|doi=10.1007/BF03325227|pmc=2684987|pmid=19448391}}</ref><ref>{{Cite journal|last1=Semba|first1=R.|last2=Najjar|first2=S.|last3=Sun|first3=K.|last4=Lakatta|first4=E.|last5=Ferrucci|first5=L.|year=2009|title=Serum carboxymethyl-lysine, an advanced glycation end product, is associated with increased aortic pulse wave velocity in adults|journal=American Journal of Hypertension|volume=22|issue=1|pages=74–79|doi=10.1038/ajh.2008.320|pmc=2637811|pmid=19023277}}</ref> Produk akhir proses glikasi diyakini merupakan penyebab komplikasi vaskuler pada diabetes.<ref>{{Cite journal|last1=Yan|first1=S. F.|last2=D'Agati|first2=V.|last3=Schmidt|first3=A. M.|last4=Ramasamy|first4=R.|year=2007|title=Receptor for Advanced Glycation Endproducts (RAGE): a formidable force in the pathogenesis of the cardiovascular complications of diabetes & aging|journal=Current Molecular Medicine|volume=7|issue=8|pages=699–710|doi=10.2174/156652407783220732|pmid=18331228}}</ref>