Sertralin: Perbedaan antara revisi
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<!--Legal data-->|DailyMedID=Sertraline|legal_AU=S4|legal_UK=POM|legal_US=Perlu resep dokter|legal_status=Perlu resep dokter
<!--Pharmacokinetic data-->|bioavailability=44%|protein_bound=98.5%|metabolism=[[Liver]] (''N''-[[demethylation]] utamanya oleh enzim [[CYP2B6]])<ref name="pmid15547048">{{cite journal |last1=Obach |first1=RS |last2=Cox |first2=LM |last3=Tremaine |first3=LM |title=Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. |journal=Drug metabolism and disposition: the biological fate of chemicals |date=Februari 2005 |volume=33 |issue=2 |pages=262-70 |doi=10.1124/dmd.104.002428 |pmid=15547048}}</ref>|metabolites=Norsertraline|elimination_half-life=~23–26 jam (66 jam [keaktifan berkurang<ref name=FDALabel>[http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019839s084,020990s043lbl.pdf Sertraline FDA Label] {{Webarchive|url=https://web.archive.org/web/20201030062001/https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019839s084,020990s043lbl.pdf |date=30 October 2020|title=Wayback Machine}} Last updated May 2014</ref> metabolite, norsertraline])<ref name="GG">Brunton L, Chabner B, Knollman B. (2010) ''Goodman and Gilman’s The Pharmacological Basis of Therapeutics'', Twelfth Edition. McGraw Hill Professional. {{ISBN|9780071769396}}</ref><ref name="pmid16192315">{{cite journal | vauthors = Obach RS, Walsky RL, Venkatakrishnan K, Gaman EA, Houston JB, Tremaine LM | s2cid = 12975686 | title = The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 316 | issue = 1 | pages = 336–48 | date = January 2006 | pmid = 16192315 | doi = 10.1124/jpet.105.093229 }}</ref><ref name="pmid12452737">{{cite journal | vauthors = DeVane CL, Liston HL, Markowitz JS | s2cid = 28720641 | title = Clinical pharmacokinetics of sertraline | journal = Clinical Pharmacokinetics | volume = 41 | issue = 15 | pages = 1247–66 | year = 2002 | pmid = 12452737 | doi = 10.2165/00003088-200241150-00002 }}</ref><ref name="pmid14709940">{{cite journal | vauthors = DeVane CL, Donovan JL, Liston HL, Markowitz JS, Cheng KT, Risch SC, Willard L | s2cid = 25826168 | title = Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers | journal = Journal of Clinical Psychopharmacology | volume = 24 | issue = 1 | pages = 4–10 | date = February 2004 | pmid = 14709940 | doi = 10.1097/01.jcp.0000104908.75206.26 }}</ref>|excretion=Ginjal
<!--Chemical data-->|C=17|H=17|Cl=2|N=1|SMILES=ClC1=CC=C([C@H]2C3=C([C@H](CC2)NC)C=CC=C3)C=C1Cl|StdInChI_Ref={{stdinchicite|correct|chemspider}}|StdInChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1|StdInChIKey_Ref={{stdinchicite|correct|chemspider}}|StdInChIKey=VGKDLMBJGBXTGI-SJCJKPOMSA-N}}
Baris 19:
Sertraline pertama kali disetujui untuk penggunaan medis di Amerika Serikat pada tahun 1991 dan awalnya dijual oleh [[Pfizer]].<ref name="AHFS2018" /> Saat ini, sertraline banyak tersedia sebagai [[obat generik]].<ref name="AHFS2018" /> Sertraline termasuk ke dalam [[Daftar Obat Esensial Organisasi Kesehatan Dunia|Daftar Obat Esensial yang dirumuskan Organisasi Kesehatan Dunia (WHO)]]. <ref name="WHO22nd">{{Cite book|vauthors=((World Health Organization))|year=2021|title=World Health Organization model list of essential medicines: 22nd list (2021)|location=Geneva|publisher=World Health Organization|hdl=10665/345533|id=WHO/MHP/HPS/EML/2021.02|author-link=World Health Organization|hdl-access=free}}</ref> Di Amerika Serikat, harga obat yang dijual grosir adalah [[Dolar Amerika Serikat|$ AS]] 1,50 per bulannya pada 2018.<ref name="ref1">{{Cite web|title=NADAC as of 2018-01-03|url=https://data.medicaid.gov/Drug-Pricing-and-Payment/NADAC-as-of-2018-01-03/v54n-gpyk|website=Centers for Medicare and Medicaid Services|archive-url=https://web.archive.org/web/20190624045037/https://data.medicaid.gov/Drug-Pricing-and-Payment/NADAC-as-of-2018-01-03/v54n-gpyk|archive-date=24 June 2019|access-date=7 January 2018|url-status=dead}}</ref> Pada tahun 2016, sertraline adalah obat psikiatri yang paling sering diresepkan di Amerika Serikat,<ref name="PsychCentral2">{{Cite web|last=Grohol, John M.|date=12 October 2017|title=Top 25 Psychiatric Medications for 2016|url=https://psychcentral.com/blog/top-25-psychiatric-medications-for-2016/|website=Psych Central|archive-url=https://web.archive.org/web/20200920034004/https://psychcentral.com/blog/top-25-psychiatric-medications-for-2016/|archive-date=20 September 2020|access-date=October 22, 2018|url-status=live}}</ref> dengan lebih dari 37 juta resep diberikan.<ref name="Sertraline Hydrochloride - Drug Usage Statistics">{{Cite web|date=23 December 2019|title=Sertraline Hydrochloride - Drug Usage Statistics|url=https://clincalc.com/DrugStats/Drugs/SertralineHydrochloride|website=ClinCalc|archive-url=https://web.archive.org/web/20200411214351/https://clincalc.com/DrugStats/Drugs/SertralineHydrochloride|archive-date=11 April 2020|access-date=11 April 2020|url-status=dead}}</ref> Sedangkan pada 2017, sertraline adalah obat ke-14 yang paling sering diresepkan di Amerika Serikat dengan lebih dari 38 juta resep diberikan.<ref name="ref">{{Cite web|title=The Top 300 of 2020|url=https://clincalc.com/DrugStats/Top300Drugs.aspx|website=ClinCalc|archive-url=https://web.archive.org/web/20200318234059/https://clincalc.com/DrugStats/Top300Drugs.aspx|archive-date=18 March 2020|access-date=11 April 2020|url-status=live}}</ref> <ref name="Sertraline Hydrochloride - Drug Usage Statistics" />
== Referensi ==
{{Reflist|30em}}
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