Pengguna:Rizhmd21/Draf: Perbedaan antara revisi

The concentration of methylphenidate or [[ritalinic acid]], its major [[metabolite]], may be quantified in plasma, serum or whole blood in order to monitor compliance in those receiving the drug therapeutically, to confirm the diagnosis in potential poisoning victims or to assist in the forensic investigation in a case of fatal overdosage.<ref>R. Baselt, ''Disposition of Toxic Drugs and Chemicals in Man'', 9th edition, Biomedical Publications, Seal Beach, CA, 2011, pp. 1091–93.</ref>

 

 

Methylphenidate was first made in 1944,<ref>{{Cite journal| author = Panizzon L | title = La preparazione di piridile piperidil-arilacetonitrili e di alcuni prodotti di trasformazione (Parte Ia) | journal = Helvetica Chimica Acta | volume = 27 | pages = 1748–56 | year = 1944 | doi = 10.1002/hlca.194402701222}}</ref> and was identified as a stimulant in 1954.<ref>{{cite journal | vauthors = Meier R, Gross F, Tripod J | title = [Ritalin, a new synthetic compound with specific analeptic components] | journal = Klinische Wochenschrift | volume = 32 | issue = 19–20 | pages = 445–50 | date = May 1954 | pmid = 13164273 | doi = 10.1007/BF01466968 }}</ref>