Titrasi obat: Perbedaan antara revisi

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Wiz Qyurei (bicara | kontrib)
←Membuat halaman berisi 'thumb|300px|Kurva respons dosis terapeutik (hijau) dan efek samping (merah) yang menggambarkan dosis titrasi awal dan semakin meningkat (panah). '''Titrasi obat''' adalah proses penyesuaian dosis suatu obat untuk mendapatkan manfaat maksimal tanpa efek samping.<ref>{{cite book | vauthors = Maxwell S | veditors = Walker BR, Colledge NR, Ralston SH, Penman ID | chapter = Chapter 2: Therapeutics and Good Prescribing...'
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'''Titrasi obat''' adalah proses penyesuaian [[dosis]] suatu [[medikasi|obat]] untuk mendapatkan manfaat maksimal tanpa [[efek samping]].<ref>{{cite book | vauthors = Maxwell S | veditors = Walker BR, Colledge NR, Ralston SH, Penman ID | chapter = Chapter 2: Therapeutics and Good Prescribing: Choosing a Dosing Regime | title = Davidson's Principles and Practice of Medicine |date=2013 |publisher=Elsevier Health Sciences |isbn=978-0-7020-5103-6 |pages=34 | chapter-url = https://books.google.com/books?id=W-5kAgAAQBAJ&pg=PA34 }}</ref>
 
Ketika suatu obat memiliki [[indeks terapeutik]] yang sempit, titrasi sangatlah penting, karena kisaran antara dosis efektif suatu obat dan dosis terjadinya efek samping kecil.<ref>{{cite book | vauthors = Schachter M, Pirmohamed M| veditors = Bennett PN, Brown MJ, Sharma P | chapter = General Pharmacology |title=Clinical Pharmacology | url = https://archive.org/details/clinicalpharmaco0000benn_v5q7|date=2012 |publisher=Elsevier |pages=74–109[https://archive.org/details/clinicalpharmaco0000benn_v5q7/page/74 74]–109 |edition=11 |isbn = 978-0-7020-4084-9 }}</ref> Beberapa contoh jenis obat yang umumnya memerlukan titrasi antara lain [[insulin]], [[antikejang|antikonvulsan]], [[antikoagulan|pengencer darah]], [[antidepresan]], dan [[sedatif|obat penenang]].<ref>{{cite book | vauthors = Roden DM | chapter = Chapter 5 : Principles of Clinical Pharmacology | veditors = Kasper D, Fauci A, Hauser S, Longo D,Jameson JL, Loscalzo J | title = Principles of Clinical Pharmacology | edition = 19 | isbn = 978-0-07-180215-4 | location = New York, NY | publisher = McGraw-Hill | date = 2014 }}</ref><ref>{{cite book | veditors = Olson KR, Anderson IB, Benowitz NL, Blanc PD, Clark RF, Kearney TE, Kim-Katz SY, Wu AH | chapter = Section III: Therapeutic Drugs and Antidotes | title = Poisoning & Drug Overdose | date = 11 Desember 2017 | edition = 7 | isbn = 978-0-07-183979-2 | location = New York, NY | publisher = McGraw-Hill }}</ref><ref>{{cite book | vauthors = Kruidering-Hall M, Campbell L | chapter = Chapter 27: Skeletal Muscle Relaxants | veditors = Katzung BG | title = Basic & Clinical Pharmacology | date = 30 November 2017 | edition = 14 | location = New York, NY | publisher = McGraw-Hill | isbn = 978-1-259-64115-2 }}</ref>
 
Disarankan untuk melakukan titrasi obat dibandingkan menghentikannya secara tiba-tiba dalam beberapa situasi. [[Glukokortikoid]] harus dikurangi setelah penggunaan jangka panjang untuk menghindari insufisiensi adrenal.<ref>{{cite book | vauthors = Furst DE, Saag KG | veditors = Matteson EL, Curtis MR | chapter = Glucocorticoid withdrawal | title = Treatment Issues in Rheumatology | chapter-url=https://www.uptodate.com/contents/glucocorticoid-withdrawal | website = UpToDate |accessdate=1 Januari 2024}}</ref>