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<!-- Clinical data -->|pregnancy_AU=C|pregnancy_US=C|pregnancy_category=|routes_of_administration=By mouth, [[suppository|rectal]], [[intravenous therapy|IV]], [[intramuscular injection|IM]], [[topical]]|Drugs.com={{drugs.com|monograph|promethazine-hydrochloride}}|MedlinePlus=a682284
<!-- Legal data -->|legal_AU=S3|legal_CA=OTC|legal_UK=P|legal_US=Rx-only|legal_status=South Africa: S5 IV S2 Oral|licence_US=|licence_EU=<!-- Pharmacokinetic data -->|bioavailability=88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability<ref name="pmid10965395">{{cite journal |vauthors=Strenkoski-Nix LC, Ermer J, DeCleene S, Cevallos W, Mayer PR | title = Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects | journal = American Journal of Health-System Pharmacy | volume = 57 | issue = 16 | pages = 1499–505 |date=August 2000 | pmid = 10965395 | doi = 10.1093/ajhp/57.16.1499}}</ref>|protein_bound=93%|metabolism=[[Liver]] [[glucuronidation]] and [[sulfoxide|sulfoxidation]]|elimination_half-life=10–19 hours<ref name="pmid10965395">{{cite journal |vauthors=Strenkoski-Nix LC, Ermer J, DeCleene S, Cevallos W, Mayer PR | title = Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects | journal = American Journal of Health-System Pharmacy | volume = 57 | issue = 16 | pages = 1499–505 |date=August 2000 | pmid = 10965395 | doi = 10.1093/ajhp/57.16.1499}}</ref><ref name="pmid2866055">{{cite journal |vauthors=Paton DM, Webster DR | title = Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines) | journal = Clinical Pharmacokinetics | volume = 10 | issue = 6 | pages = 477–97 | year = 1985 | pmid = 2866055 | doi = 10.2165/00003088-198510060-00002}}</ref>|excretion=[[Kidney]] and [[Bile|biliary]]
<!-- Chemical and physical data -->|C=17|H=20|N=2|S=1|smiles=S2c1ccccc1N(c3c2cccc3)CC(N(C)C)C|StdInChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3|StdInChI_Ref={{stdinchicite|correct|chemspider}}|StdInChIKey=PWWVAXIEGOYWEE-UHFFFAOYSA-N|StdInChIKey_Ref={{stdinchicite|correct|chemspider}}}}
'''Promethazine''' adalah obat untuk mengatasi kejadian dari [[alergi]], sulit tidur, dan juga mengatasi [[mual]] . <ref name="AHFS2018">{{Cite web|title=Promethazine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/promethazine-hydrochloride.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |archive-date=24 October 2018 |archive-url=https://web.archive.org/web/20181024073758/https://www.drugs.com/monograph/promethazine-hydrochloride.html |url-status=live |access-date=24 October 2018}}</ref> Promethazine juga bisa mengatasi gejala yang berkaitan dengan [[Pilek|flu biasa]] . <ref name="AHFS2018">{{cite web |title=Promethazine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/promethazine-hydrochloride.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=24 October 2018 |archive-date=24 October 2018 |archive-url=https://web.archive.org/web/20181024073758/https://www.drugs.com/monograph/promethazine-hydrochloride.html |url-status=live }}</ref> Obat ini juga bisa dipakai untuk membantu menenangkan orang yang sedang gelisah atau mengalami rasa cemas. <ref name="BNF74">{{Cite book|date=2017|title=British national formulary : BNF 74|publisher=British Medical Association|isbn=978-0857112989|edition=74|page=276}}</ref> <ref>{{Cite book|last=Malamed|first=Stanley F.|date=2009|url=https://books.google.ca/books?id=Abp9ci5-n1wC&pg=PA113|title=Sedation: A Guide to Patient Management|publisher=Elsevier Health Sciences|isbn=978-0323075961|page=113|language=en|access-date=2018-10-24|archive-url=https://web.archive.org/web/20181025071005/https://books.google.ca/books?id=Abp9ci5-n1wC&pg=PA113|archive-date=2018-10-25|url-status=live}}</ref> Obat ini memiliki beberapa sediaan, ada sediaan oral dalam bentuk sirup, ada sediaan [[Supositoria|supositoria rektal]], dan sediaan injeksi yang digunakan melalui [[Penyuntikan intraotot|suntikan ke otot]] . <ref name="AHFS2018">{{cite web |title=Promethazine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/promethazine-hydrochloride.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=24 October 2018 |archive-date=24 October 2018 |archive-url=https://web.archive.org/web/20181024073758/https://www.drugs.com/monograph/promethazine-hydrochloride.html |url-status=live }}</ref>
Kejadian efek samping dari obat ini yang umum yakni rasa kebingungan dan rasa mengantuk. <ref name="AHFS2018" /> Konsumsi alkohol ataupun obat golongan penenang lainnya bisa memperburuk kondisi. <ref name="AHFS2018" /> Belum diketahui status keamanan untuk penggunaan ibu [[Kehamilan|hamil]] dan juga ibu [[menyusui]]. <ref name="AHFS2018" /> <ref name="BNF74" /> Penggunaan obat ini tidak direkomendasikan untuk anak usia kurang dari dua tahun disebabkan, memiliki potensi gangguan pada pernapasan. <ref name="AHFS2018" /> Promethazine termasuk [[Antihistamina|antihistamin]] generasi pertama dalam keluarga obat fenotiazin . <ref name="AHFS2018" />
Kejadian efek samping dari obat ini yang umum yakni rasa kebingungan dan rasa mengantuk. <ref name="AHFS2018">{{Cite web|title=Promethazine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/promethazine-hydrochloride.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |archive-date=24 October 2018 |archive-url=https://web.archive.org/web/20181024073758/https://www.drugs.com/monograph/promethazine-hydrochloride.html |url-status=live |access-date=24 October 2018}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/promethazine-hydrochloride.html "Promethazine Hydrochloride Monograph for Professionals"]. ''Drugs.com''. American Society of Health-System Pharmacists. [https://web.archive.org/web/20181024073758/https://www.drugs.com/monograph/promethazine-hydrochloride.html Archived] from the original on 24 October 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">24 October</span> 2018</span>.</cite></ref> Konsumsi alkohol ataupun obat golongan penenang lainnya bisa memperburuk kondisi. <ref name="AHFS2018">{{cite web |title=Promethazine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/promethazine-hydrochloride.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=24 October 2018 |archive-date=24 October 2018 |archive-url=https://web.archive.org/web/20181024073758/https://www.drugs.com/monograph/promethazine-hydrochloride.html |url-status=live }}</ref> Belum diketahui status keamanan untuk penggunaan ibu [[Kehamilan|hamil]] dan juga ibu [[menyusui]]. <ref name="AHFS2018">{{cite web |title=Promethazine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/promethazine-hydrochloride.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=24 October 2018 |archive-date=24 October 2018 |archive-url=https://web.archive.org/web/20181024073758/https://www.drugs.com/monograph/promethazine-hydrochloride.html |url-status=live }}</ref> <ref name="BNF74">{{Cite book|date=2017|title=British national formulary : BNF 74|publisher=British Medical Association|isbn=978-0857112989|edition=74|page=276}}<cite class="citation book cs1" data-ve-ignore="true">''British national formulary : BNF 74'' (74 ed.). </cite></ref> Penggunaan obat ini tidak direkomendasikan untuk anak usia kurang dari dua tahun disebabkan, memiliki potensi gangguan pada pernapasan. <ref name="AHFS2018">{{cite web |title=Promethazine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/promethazine-hydrochloride.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=24 October 2018 |archive-date=24 October 2018 |archive-url=https://web.archive.org/web/20181024073758/https://www.drugs.com/monograph/promethazine-hydrochloride.html |url-status=live }}</ref> Promethazine termasuk [[Antihistamina|antihistamin]] generasi pertama dalam keluarga obat fenotiazin . <ref name="AHFS2018">{{cite web |title=Promethazine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/promethazine-hydrochloride.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=24 October 2018 |archive-date=24 October 2018 |archive-url=https://web.archive.org/web/20181024073758/https://www.drugs.com/monograph/promethazine-hydrochloride.html |url-status=live }}</ref>
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