Triptase: Perbedaan antara revisi

'''Tryptase''' ({{EC number|3.4.21.59}}, ) adalah [[Serina|serin]] proteinase terbanyak yang berasal dari granul sekresi dalam [[Mastosit|sel mast]] dan telah digunakan sebagai penanda untuk aktivasi sel mast.<ref name="pmid6358206">{{Cite journal|date=November 1983|title=Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates|url=http://www.jbc.org/content/258/22/13552.full.pdf|journal=J. Biol. Chem.|volume=258|issue=22|pages=13552–7|pmid=6358206}}</ref><ref name="pmid2187193">{{Cite journal|date=May 1990|title=Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family|journal=Proc. Natl. Acad. Sci. U.S.A.|volume=87|issue=10|pages=3811–5|doi=10.1073/pnas.87.10.3811|pmc=53993|pmid=2187193}}</ref><ref>{{Cite journal|year=1985|title=Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions|journal=Arch. Biochem. Biophys|volume=239|pages=436–443|doi=10.1016/0003-9861(85)90709-X|pmid=3890754}}</ref><ref>{{Cite journal|year=1987|title=Human pituitary tryptase: molecular forms, NH₂-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates|journal=J. Biol. Chem.|volume=262|pages=1363–1373|pmid=3543004}}</ref><ref>{{Cite journal|year=1988|title=Human skin tryptase: purification, partial characterization and comparison with human lung tryptase|journal=Biochim. Biophys. Acta|volume=957|pages=71–80|doi=10.1016/0167-4838(88)90158-6|pmid=3140898}}</ref> Sel Clara yang mengandung '''triptase''' diyakini bertanggung jawab dalam pemecahan protein [[hemaglutinin]] dari [[virus influenza A]], sehingga mengaktifkan dan menyebabkan gejala flu.<ref>{{Cite journal|last=Taubenberger|first=JK|date=Aug 1998|title=Influenza virus hemagglutinin cleavage into HA1, HA2: No laughing matter|journal=Proc Natl Acad Sci U S A|volume=95|pages=9713–5|doi=10.1073/pnas.95.17.9713|pmc=33880|pmid=9707539}}</ref>

Kadar dalam serum biasanya kurang dari 11,5&nbsp;ng/mL.<ref>[http://www.mayomedicallaboratories.com/test-catalog/print/91815 Mayo Clinic > Test ID: FFTRS91815, Tryptase]{{Pranala mati|date=April 2021 |bot=InternetArchiveBot |fix-attempted=yes }}.</ref> Peningkatan kadar serum triptase terjadi pada [[anafilaksis]] dan reaksi anafilaktoid, tetapi hasil tes negatif tidak menyingkirkan kemungkinan [[anafilaksis]]. Triptase tidak terlalu meningkat pada reaksi alergi makanan, berbeda dengan anafilaksis oleh penyebab lain. Kadar triptase dalam serum juga digunakan sebagai salah satu indikasi yang menunjukkan adanya leukemia eosinofilik karena [[mutasi]] genetik yang mengakibatkan pembentukan gen fusi ''FIP1L1-PDGFRA'' atau adanya mastositosis sistemik.<ref name="pmid26276769">{{Cite journal|year=2015|title=Hematolymphoid neoplasms associated with rearrangements of PDGFRA, PDGFRB, and FGFR1|journal=American Journal of Clinical Pathology|volume=144|issue=3|pages=377–92|doi=10.1309/AJCPMORR5Z2IKCEM|pmid=26276769}}</ref><ref name="pmid28254862">{{Cite journal|year=2017|title=Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future|journal=Cancer Research|volume=77|issue=6|pages=1261–1270|doi=10.1158/0008-5472.CAN-16-2234|pmid=28254862}}</ref>