Erdostein: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
←Membuat halaman berisi ''''Erdostein''' adalah suatu molekul dengan aktivitas mukolitik. Secara struktural merupakan turunan tiol yang ditandai dengan adanya dua gugus tiol.<ref>{{cite journal | vauthors = Gobetti M, Pedrazzoli A, Bradamante S | title = DL-S-(2-[N-3-(2-oxo-tetrahydrothienyl)acetamido])-thioglycolic acid: a novel mucolytic agent of the class of homocysteine thiolactone derivatives | journal = Il Farmaco; Edizione Scientifica | volume = 41 | issue = 1 | page...' Tag: Suntingan perangkat seluler Suntingan peramban seluler Suntingan seluler lanjutan |
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Baris 1:
{{short description|Chemical to treat chronic bronchitis}}
{{Drugbox
| verifiedrevid = 447814556
| IUPAC_name = 2-[(2-Oksotiolan-3-il)karbamoilmetilsulfanil]asam asetat
| image = erdosteine.png
<!--Clinical data-->
| tradename =
| Drugs.com = {{drugs.com|international|erdosteine}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =
| routes_of_administration = Oral, inhalasi
<!--Pharmacokinetic data-->
| bioavailability =
| protein_bound = 65%
| metabolism = Hati
| elimination_half-life = 1–3 jam
| excretion =
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 84611-23-4
| ATC_prefix = R05
| ATC_suffix = CB15
| ChEMBL = 1697744
| PubChem = 65632
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 59073
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 76J0853EKA
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07383
<!--Chemical data-->
| C=8 | H=11 | N=1 | O=4 | S=2
| smiles = O=C1SCCC1NC(=O)CSCC(=O)O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = QGFORSXNKQLDNO-UHFFFAOYSA-N
}}
'''Erdostein''' adalah suatu molekul dengan aktivitas [[mukolitik]]. Secara struktural merupakan turunan [[tiol]] yang ditandai dengan adanya dua gugus tiol.<ref>{{cite journal | vauthors = Gobetti M, Pedrazzoli A, Bradamante S | title = DL-S-(2-[N-3-(2-oxo-tetrahydrothienyl)acetamido])-thioglycolic acid: a novel mucolytic agent of the class of homocysteine thiolactone derivatives | journal = Il Farmaco; Edizione Scientifica | volume = 41 | issue = 1 | pages = 69–79 | date = January 1986 | pmid = 3956722 }}</ref> Kedua gugus sulfhidril fungsional yang terkandung dalam molekul dilepaskan setelah metabolisme lintas pertama dengan konversi erdostein menjadi metabolit Met-I yang aktif secara farmakologis.
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