Sel punca kanker: Perbedaan antara revisi
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Sejumlah penanda permukaan sel seperti [[CD44]], [[CD24]], dan [[CD133]] sering digunakan untuk mengidentifikasi CSC.<ref name=":0" /> Jejaring regulasi gen yang terdiri dari [[mikroRNA]] dan jalur pensinyalan [[Wnt/β-catenin]], [[Jalur persinyalan Notch|Notch]], dan [[Jalur persinyalan Hedgehog|Hedgehog]] diketahui dapat mengatur sifat dan karakteristik CSC.<ref name=":0" /> Bebepara penelitian<ref>{{Cite journal|last=Li|first=X.|last2=Lewis|first2=M. T.|last3=Huang|first3=J.|last4=Gutierrez|first4=C.|last5=Osborne|first5=C. K.|last6=Wu|first6=M.-F.|last7=Hilsenbeck|first7=S. G.|last8=Pavlick|first8=A.|last9=Zhang|first9=X.|date=2008-05-07|title=Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy|url=https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djn123|journal=JNCI Journal of the National Cancer Institute|language=en|volume=100|issue=9|pages=672–679|doi=10.1093/jnci/djn123|issn=0027-8874}}</ref><ref>{{Cite journal|last=Meirelles|first=Katia|last2=Benedict|first2=Leo Andrew|last3=Dombkowski|first3=David|last4=Pepin|first4=David|last5=Preffer|first5=Frederic I.|last6=Teixeira|first6=Jose|last7=Tanwar|first7=Pradeep Singh|last8=Young|first8=Robert H.|last9=MacLaughlin|first9=David T.|date=2012-02-14|title=Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance|url=https://pnas.org/doi/full/10.1073/pnas.1120733109|journal=Proceedings of the National Academy of Sciences|language=en|volume=109|issue=7|pages=2358–2363|doi=10.1073/pnas.1120733109|issn=0027-8424|pmc=PMC3289387|pmid=22308459}}</ref><ref>{{Cite journal|last=Yu|first=Zuoren|last2=Willmarth|first2=Nicole E.|last3=Zhou|first3=Jie|last4=Katiyar|first4=Sanjay|last5=Wang|first5=Min|last6=Liu|first6=Yang|last7=McCue|first7=Peter A.|last8=Quong|first8=Andrew A.|last9=Lisanti|first9=Michael P.|date=2010-05-04|title=microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling|url=https://pnas.org/doi/full/10.1073/pnas.1002080107|journal=Proceedings of the National Academy of Sciences|language=en|volume=107|issue=18|pages=8231–8236|doi=10.1073/pnas.1002080107|issn=0027-8424|pmc=PMC2889540|pmid=20406904}}</ref> menunjukkan bahwa CSC resisten terhadap [[kemoterapi]] konvensional dan [[Radioterapi|terapi radiasi]], menyebabkan CSC menjadi salah satu target terapi yang menjanjikan.<ref name=":0" />
Sel punca kanker pertama kali diidentifikasi oleh [[John Dick (ahli biologi)|John Dick]] pada [[Leukemia mieloid akut|leukemia myeloid akut]] di akhir tahun 1990-an.<ref>{{Cite news|last=Mukherjee|first=Siddhartha|date=2010-10-29|title=The Cancer Sleeper Cell|url=https://www.nytimes.com/2010/10/31/magazine/31Cancer-t.html|newspaper=The New York Times|language=en-US|issn=0362-4331|access-date=2024-04-09}}</ref> Sejak awal tahun 2000-an, CSC telah menjadi fokus penelitian kanker yang intens. Istilah sel punca kanker sendiri pertama kali dicetuskan dalam risalah yang terbit tahun 2001 oleh ahli biologi Tannishtha Reya, Sean J. Morrison, Michael F. Clarke, dan Irving Weissman.<ref>{{Cite journal|last=Reya|first=Tannishtha|last2=Morrison|first2=Sean J.|last3=Clarke|first3=Michael F.|last4=Weissman|first4=Irving L.|date=2001-11|title=Stem cells, cancer, and cancer stem cells|url=https://www.nature.com/articles/35102167|journal=Nature|language=en|volume=414|issue=6859|pages=105–111|doi=10.1038/35102167|issn=0028-0836}}</ref>
== Referensi ==
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