Flutikason: Perbedaan antara revisi
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Baris 1:
{{Short description|Chemical compound}}
{{Use dmy dates|date=October 2022}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 458449795
| image = Fluticasone.svg
| width = 200
<!--Clinical data-->
| Drugs.com =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_category =
| routes_of_administration = Intra[[Pemberian hidung|nasal]], inhalasi, [[Topikal]]
| ATC_prefix = D07
| ATC_suffix = AC17
| ATC_supplemental = {{ATC|R01|AD08}} {{ATC|R03|BA05}} {{ATC|R01|AD58}}
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S8 -->
| legal_CA = OTC <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
<!--Pharmacokinetic data-->
| bioavailability = 0.51% (Intranasal)
| protein_bound = 91.0%
| metabolism = Intranasal<br />[[Hati]] ([[CYP3A4]]-dimediasi)
| elimination_half-life = 10 jam
| excretion = [[Ginjal]]
<!--Identifiers-->
| IUPHAR_ligand = 6699
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 90566-53-3
| PubChem = 5311101
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB00588
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4470631
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = CUT2W21N7U
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07981
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 5134
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1201396
| synonyms = 6α,9α-Difluoro-11β,17α-dihidroksi-16α-metil-21-tia-21-fluorometilpregna-1,4-dien-3,20-diona; ''S''-(Fluorometil)-6α,9α-difluoro-11β,17α-dihidroksi-16α-metil-3-oksoandrosta-1,4-diena-17β-karbotioat
<!--Chemical data-->
| IUPAC_name = ''S''-fluorometil (6''S'',8''S'',9''R'',10''S'',11''S'',13''S'',14''S'',16''R'',17''R'')-6,9-difluoro-11,17-dihidroksi-10,13,16-trimetil-3-okso-6,7,8,11,12,14,15,16-oktahidrosiklopenta[''a'']fenantrena-17-karbotioat
| C=22 | H=27 | F=3 | O=4 | S=1
| SMILES= O=C(SCF)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = MGNNYOODZCAHBA-GQKYHHCASA-N
}}
'''Flutikason''' adalah senyawa [[glukokortikoid]] yang digunakan untuk mengobati gejala penyakit [[rongga hidung]].<ref name="Elks2014">{{cite book| vauthors = Elks J |title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA574|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=574–}}</ref><ref name="IndexNominum2000">{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA1337|year=2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=1337–}}</ref><ref name="MortonHall2012">{{cite book| vauthors = Morton IK, Hall JM |title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA124|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-011-4439-1|pages=124–}}</ref><ref name="Drugs.com">{{Cite web|url=https://www.drugs.com/international/fluticasone.html|title = Fluticasone - FDA prescribing information, side effects and uses}}</ref><ref name="Briggs_et_al2012" /> Baik esternya yakni flutikason propionat dan flutikason furoat, juga digunakan sebagai [[antiinflamasi]] topikal dan [[kortikosteroid]] inhalasi, dan lebih sering digunakan sebagai perbandingan.<ref name="MortonHall2012" /><ref name="IndexNominum2000" /><ref name="Drugs.com" /><ref name="SprattoWoods2012" />
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