Basitrasin: Perbedaan antara revisi
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{{Short description|Polypeptide antibiotic}}
{{Use dmy dates|date=January 2024}}
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 457285800
| image = Bacitracin A.svg
| image2 = Bacitracin ball-and-stick.png
<!-- Clinical data -->
| tradename = Baciguent, Baciim, dll
| Drugs.com = {{drugs.com|monograph|bacitracin}}
| pregnancy_AU = D
| routes_of_administration = [[Topikal]], [[Penyuntikan intraotot|intramuskular]], diteteskan melalui mata
| ATC_prefix = D06
| ATC_suffix = AX05
| ATC_supplemental = {{ATC|J01|XX10}}, {{ATC|R02|AB04}}, {{ATC|S01|AA32}}, {{ATCvet|A07|AA93}}
| legal_AU = S4
| legal_US = OTC
| legal_US_comment = / Rx-only
<!--Pharmacokinetic data-->
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 1405-87-4
| PubChem = 439542
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00626
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 10481985
| ChEBI = 28669
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 58H6RWO52I
| KEGG_Ref = {{keggcite|changed|kegg}}
| KEGG = D00128
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1200558
<!--Chemical data-->
| IUPAC_name = (4''R'')-4-[(2''S'')-2-({2-[(1''S'')-1-amino-2-metilbutil]- 4,5-dihidro-1,3-tiazol-5-yl}formamido)-4-metilpentanamido]-4-<nowiki/>{[(1''S'')- 1-<nowiki/>{[(3''S'',6''R'',9''S'',12''R'',15''S'',18''R'',21''S'')- 18-(3-aminopropil)-12-benzil-15-(butan-2-il)-3-(karbamoilmetil)- 6-(karboksimetil)-9-(1''H''-imidazol-5-ilmetil)-2,5,8,11,14,17,20- heptaokso-1,4,7,10,13,16,19-heptaazasiklopentakosan-21-il]karbamoil}- 2-metilbutil]karbamoil}asam butanoat
| C=66 | H=103
| N=17 | O=16
| S=1
| smiles = CCC(C)C(N)NC4=NC(C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C(C)CC)C(=O)N[C@H]3CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C(C)CC)NC(=O)[C@@H](CCCN)NC3=O)CS4
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36?,37?,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = CLKOFPXJLQSYAH-NVOBBBONSA-N
}}
'''Basitrasin''' adalah salah satu [[antibiotik]] polipeptida. Obat ini merupakan campuran peptida siklik terkait yang diproduksi oleh bakteri ''Bacillus licheniformis'', yang pertama kali diisolasi dari varietas "Tracy I" (ATCC 10716) pada tahun 1945.<ref>Originally grouped under ''B. subtilis'', but nomenclature has since changed. See {{cite web | vauthors = Podstawka A |title=Bacillus licheniformis Tracy I {{!}} DSM 603, ATCC 10716, CCM 2181, IFO 12199, NBRC 12199, NCIB 8874, FDA BT1 {{!}} BacDiveID:686 |url=https://bacdive.dsmz.de/strain/686 |website=bacdive.dsmz.de |language=en |access-date=7 February 2022 |archive-date=7 February 2022 |archive-url=https://web.archive.org/web/20220207144504/https://bacdive.dsmz.de/strain/686 |url-status=live }}</ref> [[Peptida]] ini mengganggu [[bakteri]] [[gram-positif]] dengan mengganggu [[dinding sel]] dan sintesis [[peptidoglikan]].
Obat ini terutama digunakan sebagai sediaan topikal, karena dapat menyebabkan kerusakan ginjal jika digunakan secara internal.<ref name="Zintel">{{cite journal | vauthors = Zintel HA, Ma RA | title = The absorption, distribution, excretion and toxicity of bacitracin in man | journal = The American Journal of the Medical Sciences | volume = 218 | issue = 4 | pages = 439–445 | date = October 1949 | pmid = 18140540 | doi = 10.1097/00000441-194910000-00012 | s2cid = 2371497 }}</ref> Umumnya aman bila digunakan secara topikal, namun dalam kasus yang jarang terjadi dapat menyebabkan reaksi [[hipersensitivitas]], [[alergi]], atau [[anafilaksis]], terutama pada orang yang alergi terhadap [[neomisin]].<ref>{{cite journal | vauthors = Spann CT, Taylor SC, Weinberg JM | title = Topical antimicrobial agents in dermatology | journal = Disease-a-Month | volume = 50 | issue = 7 | pages = 407–421 | date = July 2004 | pmid = 15280871 | doi = 10.1016/j.disamonth.2004.05.011 }}</ref><ref>{{cite journal | vauthors = Trookman NS, Rizer RL, Weber T | title = Treatment of minor wounds from dermatologic procedures: a comparison of three topical wound care ointments using a laser wound model | journal = Journal of the American Academy of Dermatology | volume = 64 | issue = 3 Suppl | pages = S8-15 | date = March 2011 | pmid = 21247665 | doi = 10.1016/j.jaad.2010.11.011 | doi-access = free }}</ref>
== Sejarah ==
== Kegunaan dalam Medis ==
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