Timolol: Perbedaan antara revisi
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{{Infobox drug
| Watchedfields = changed
| verifiedrevid = 457286138
| image = Timolol structure.svg
| width = 200
| alt =
| image2 =Timolol ball-and-stick.png
| width2 =
| alt2 =
| caption =
<!-- Clinical data -->
| pronounce =
| tradename = Betimol, Blocadren, Istalol, Timoptic, dll<ref name=genericnames/>
| Drugs.com = Maleate {{drugs.com|monograph|maleate}}<br />eent {{drugs.com|monograph|timolol-eent}}
| MedlinePlus = a684029
| DailyMedID = Timolol
| pregnancy_AU = C
| pregnancy_AU_comment =
| pregnancy_category=
| routes_of_administration = Oral, topikal ([[tetes mata]])
| class = [[Penyekat beta]]
| ATC_prefix = C07
| ATC_suffix = AA06
| ATC_supplemental = {{ATC|S01|ED01}} {{ATC|C07|BA06}} {{ATC|C07|DA06}}<br />Combination: {{ATC|S01|ED51}}
<!-- Legal status -->
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_AU_comment =
| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F-->
| legal_BR_comment =
| legal_CA = Rx-only
| legal_CA_comment = <ref>{{cite web | title=Product monograph brand safety updates | website=Health Canada | date=February 2024 | url=https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database/label-safety-assessment-update/product-monograph-brand-safety-updates.html | access-date=24 March 2024}}</ref>
| legal_DE = <!-- Anlage I, II, III or Unscheduled-->
| legal_DE_comment =
| legal_NZ = <!-- Class A, B, C -->
| legal_NZ_comment =
| legal_UK = POM
| legal_UK_comment =
| legal_US = Rx-only
| legal_US_comment =
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV-->
| legal_UN_comment =
| legal_status =
<!-- Pharmacokinetic data -->
| bioavailability = 60%
| protein_bound =
| metabolism = Hati (80%, terutama [[Sitokrom P450 2D6|CYP2D6]])<ref>{{cite journal | vauthors = Volotinen M, Turpeinen M, Tolonen A, Uusitalo J, Mäenpää J, Pelkonen O | title = Timolol metabolism in human liver microsomes is mediated principally by CYP2D6 | journal = Drug Metabolism and Disposition | volume = 35 | issue = 7 | pages = 1135–1141 | date = July 2007 | pmid = 17431033 | doi = 10.1124/dmd.106.012906 | s2cid = 794764 }}</ref>)
| metabolites =
| onset = 15–30 menit<ref name=AHFS2016Eye />
| elimination_half-life = 2.5–5 jam
| duration_of_action = 24 hours<ref name=AHFS2016Eye />
| excretion = [[Ginjal]]
<!-- Identifiers -->
| index2_label = as salt
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 26839-75-8
| CAS_supplemental =
| PubChem = 33624
| PubChemSubstance =
| IUPHAR_ligand = 565
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00373
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 31013
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 5JKY92S7BR
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D08600
| KEGG2_Ref = {{keggcite|correct|kegg}}
| KEGG2 = D00603
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 9599
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 499
| NIAID_ChemDB =
| PDB_ligand =
| synonyms =
<!-- Chemical and physical data -->
| IUPAC_name = (''S'')-1-(''tert''-Butilamino)-3-[(4-morfolin-4-il-1,2,5-tiadiazol-3-il)oksi]propan-2-ol
| C=13 | H=24 | N=4 | O=3 | S=1
| SMILES = CC(C)(C)NCC(O)COc1nsnc1N1CCOCC1
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C13H24N4O3S/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17/h10,14,18H,4-9H2,1-3H3/t10-/m0/s1
| StdInChI_comment =
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = BLJRIMJGRPQVNF-JTQLQIEISA-N
| density =
| density_notes =
| melting_point =
| melting_high =
| melting_notes =
| boiling_point =
| boiling_notes =
| solubility =
| sol_units =
| specific_rotation =
}}
'''Timolol''' adalah obat penghambat beta yang digunakan melalui mulut atau sebagai obat tetes mata.<ref name=AHFS2016Eye/><ref name=AHFS2016PO/> Sebagai obat tetes mata, obat ini digunakan untuk mengobati peningkatan tekanan di dalam mata seperti pada hipertensi okular dan glaukoma.<ref name=AHFS2016Eye/> Melalui mulut digunakan untuk tekanan darah tinggi, nyeri dada karena aliran darah ke jantung tidak mencukupi, untuk mencegah komplikasi lebih lanjut setelah serangan jantung, dan untuk mencegah migrain.<ref name=AHFS2016PO>{{cite web|title=Timolol Maleate|url=https://www.drugs.com/monograph/timolol-maleate.html|publisher=The American Society of Health-System Pharmacists|access-date=8 December 2016|url-status=live|archive-url=https://web.archive.org/web/20161228200029/https://www.drugs.com/monograph/timolol-maleate.html|archive-date=28 December 2016}}</ref>
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