Doksilamin: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
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Baris 94:
===Farmakodinamik===
{| class="wikitable floatright" style="font-size:small;"
|+
|-
!
|-
| {{abbrlink|SERT|
|-
| {{abbrlink|NET|Norepinephrine transporter}} || >10,000 ||
|-
| {{abbrlink|DAT|Dopamine transporter}} || >10,000 ||
|-
| [[5-HT2A receptor|5-HT<sub>2A</sub>]] || >10,000 ||
|-
| [[5-HT2C receptor|5-HT<sub>2C</sub>]] || >10,000 ||
|-
| [[Alpha-1B adrenergic receptor|α<sub>1B</sub>]] || >10,000 ||
|-
| [[Alpha-2A adrenergic receptor|α<sub>2A</sub>]] || >10,000 ||
|-
| [[Alpha-2B adrenergic receptor|α<sub>2B</sub>]] || >10,000 ||
|-
| [[Alpha-2C adrenergic receptor|α<sub>2C</sub>]] || >10,000 ||
|-
| [[Histamine H1 receptor|H<sub>1</sub>]] || 42 ||
|-
| [[Histamine H2 receptor|H<sub>2</sub>]] || {{abbr|ND|No data}} || {{abbr|ND|No data}} || {{abbr|ND|No data}}
|-
| [[Histamine H3 receptor|H<sub>3</sub>]] || >10,000 ||
|-
| [[Histamine H4 receptor|H<sub>4</sub>]] || {{abbr|ND|No data}} || {{abbr|ND|No data}} || {{abbr|ND|No data}}
|-
| [[Muscarinic acetylcholine receptor M1|M<sub>1</sub>]] || 490 ||
|-
| [[Muscarinic acetylcholine receptor M2|M<sub>2</sub>]] || 2,100 ||
|-
| [[Muscarinic acetylcholine receptor M3|M<sub>3</sub>]] || 650 ||
|-
| [[Muscarinic acetylcholine receptor M4|M<sub>4</sub>]] || 380 ||
|-
| [[Muscarinic acetylcholine receptor M5|M<sub>5</sub>]] || 180 ||
|- class="sortbottom"
| colspan="4" style="width: 1px;" |
|}
Doxylamine bertindak terutama sebagai antagonis atau agonis kebalikan dari reseptor histamin H1. Tindakan ini bertanggung jawab atas sifat antihistamin dan obat penenangnya. Pada tingkat lebih rendah, doxylamine bertindak sebagai antagonis reseptor asetilkolin muskarinik, suatu tindakan yang bertanggung jawab atas efek antikolinergik dan (pada dosis tinggi) mengigau.<ref name="pmid23229983">{{cite journal | vauthors = Vande Griend JP, Anderson SL | title = Histamine-1 receptor antagonism for treatment of insomnia | journal = Journal of the American Pharmacists Association | volume = 52 | issue = 6 | pages = e210–e219 | year = 2012 | pmid = 23229983 | doi = 10.1331/JAPhA.2012.12051 }}</ref><ref name="pmid23357028" />
===Farmakokinetik===
[[File:Doxylamine levels after a single 25 mg oral dose of doxylamine.png|thumb|left|450px|Konsentrasi doxylamine setelah dosis tunggal doksilamin oral 25 mg pada sukarelawan sehat. Sumbu X mewakili waktu dalam jam setelah dosis awal.<ref name="pmid29671128">{{cite journal | vauthors = Allison M, Hale C | title = A Phase I Study of the Pharmacokinetics and Pharmacodynamics of Intranasal Doxylamine in Subjects with Chronic Intermittent Sleep Impairment | journal = Drugs in R&D | volume = 18 | issue = 2 | pages = 129–136 | date = June 2018 | pmid = 29671128 | pmc = 5995792 | doi = 10.1007/s40268-018-0232-1 }}</ref>]]
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