Efek samping yang umum mungkin termasuk mengantuk; hidung, mulut, atau tenggorokan kering,; Sembelit,; Penglihatan kabur,; serta Merasa gelisah atau bersemangat (terutama pada anak-anak).<ref>{{Cite web |title= Dimenhydrinate |url= https://www.drugs.com/mtm/dimenhydrinate.html#side-effects |url-status=live |website=Drugs.com |archive-url= https://web.archive.org/web/20040528004841/http://www.drugs.com:80/MTM/dimenhydrinate.html |archive-date=28 May 2004|access-date=28 May 2004 }}</ref> Penggunaan obat [[antikolinergik]] secara terus-menerus dan/atau kumulatif, termasuk antihistamin generasi pertama, dikaitkan dengan risiko penurunan kognitif dan [[demensia]] yang lebih tinggi pada orang lanjut usia.<ref>{{cite journal | vauthors = Gray SL, Anderson ML, Dublin S, Hanlon JT, Hubbard R, Walker R, Yu O, Crane PK, Larson EB | display-authors = 6 | title = Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study | journal = JAMA Internal Medicine | volume = 175 | issue = 3 | pages = 401–407 | date = March 2015 | pmid = 25621434 | pmc = 4358759 | doi = 10.1001/jamainternmed.2014.7663 | author5-link = Rebecca Hubbard }}</ref><ref>{{cite journal | vauthors = Carrière I, Fourrier-Reglat A, Dartigues JF, Rouaud O, Pasquier F, Ritchie K, Ancelin ML | title = Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study | journal = Archives of Internal Medicine | volume = 169 | issue = 14 | pages = 1317–1324 | date = July 2009 | pmid = 19636034 | pmc = 2933398 | doi = 10.1001/archinternmed.2009.229 }}</ref>
