PiracetamPirasetam dapat memfasilitasi deformabilitas eritrosit di pembuluh kapiler yang berguna untuk penyakit kardiovaskular.<ref name=Winblad2005/><ref name="(eMC) 2017"/>
Efek vaskular perifer dari piracetam menunjukkan potensi penggunaannya untuk [[vertigo]], [[disleksia]], fenomena[[sindrom Raynaud]], dan [[anemia sel sabit]].<ref name=Winblad2005/><ref name="(eMC) 2017"/> Tidak ada bukti yang mendukung penggunaan piracetampirasetam dalam pencegahan krisis sel sabit<ref>{{cite journal | vauthors = Al Hajeri A, Fedorowicz Z | title = Piracetam for reducing the incidence of painful sickle cell disease crises | journal = The Cochrane Database of Systematic Reviews | volume = 2 | pages = CD006111 | date = February 2016 | issue = 4 | pmid = 26869149 | pmc = 7390168 | doi = 10.1002/14651858.CD006111.pub3 }}</ref> atau untuk gawat janin saat melahirkan.<ref>{{cite journal | vauthors = Hofmeyr GJ, Kulier R | title = Piracetam for fetal distress in labour | journal = The Cochrane Database of Systematic Reviews | issue = 6 | pages = CD001064 | date = June 2012 | volume = 2012 | pmid = 22696322 | pmc = 7048034 | doi = 10.1002/14651858.CD001064.pub2 }}</ref> Tidak ada bukti manfaat piracetampirasetam pada [[strok]] iskemik akut,<ref>{{cite journal | vauthors = Ricci S, Celani MG, Cantisani TA, Righetti E | title = Piracetam for acute ischaemic stroke | journal = The Cochrane Database of Systematic Reviews | issue = 9 | pages = CD000419 | date = September 2012 | volume = 2012 | pmid = 22972044 | pmc = 7034527 | doi = 10.1002/14651858.CD000419.pub3 }}</ref> meskipun ada perdebatan mengenai kegunaannya selama rehabilitasi strokestrok.<ref>{{cite journal | vauthors = Zhang J, Wei R, Chen Z, Luo B | title = Piracetam for Aphasia in Post-stroke Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials | journal = CNS Drugs | volume = 30 | issue = 7 | pages = 575–587 | date = July 2016 | pmid = 27236454 | doi = 10.1007/s40263-016-0348-1 | s2cid = 22955205 }}</ref><ref>{{cite journal | vauthors = Yeo SH, Lim ZI, Mao J, Yau WP | title = Effects of Central Nervous System Drugs on Recovery After Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | journal = Clinical Drug Investigation | volume = 37 | issue = 10 | pages = 901–928 | date = October 2017 | pmid = 28756557 | doi = 10.1007/s40261-017-0558-4 | s2cid = 6520934 }}</ref>
